{"podcast":{"title":"Neurology Minute","slug":"neurology-minute-15117","podcast_index_feed_id":15117,"rss_url":"https://neurologyminute.libsyn.com/rss","website_url":"https://www.aan.com/education-and-research/online-learning-programs/podcasts/neurology-minute-podcast","image_url":"https://static.libsyn.com/p/assets/3/0/c/3/30c3c82925660375e55e3c100dce7605/NM_PodcastIcon_1400x1400.png","author":"Anna Rehbein","episode_count":1956,"summary":"The Neurology Minute podcast delivers a brief daily summary of what you need to know in the field of neurology, the latest science focused on the brain, and timely topics explored by leading neurologists and neuroscientists. From the American Academy of Neurology and hosted by Stacey Clardy, MD, Ph.D., FAAN, with contributions by experts from the Neurology journals, Neurology Today, Continuum, and more.","last_synced_at":"2026-06-25T18:20:17.428469+00:00","page_url":"https://stenobird.com/podcast/neurology-minute-15117"},"episode":{"title":"Shunting for Idiopathic Normal Pressure Hydrocephalus","slug":"shunting-for-idiopathic-normal-pressure-hydrocephalus","published_at":"2026-06-02T08:30:00+00:00","page_url":"https://stenobird.com/podcast/neurology-minute-15117/shunting-for-idiopathic-normal-pressure-hydrocephalus","show_page_url":"https://stenobird.com/podcast/neurology-minute-15117","url":"https://neurologyminute.libsyn.com/shunting-for-idiopathic-normal-pressure-hydrocephalus","audio_url":"https://traffic.libsyn.com/secure/neurologyminute/02_June_2nd_2026_nm_v1.mp3?dest-id=1085030","summary":"Dr. Margarita Fedorova discusses the effectiveness of shunting for idiopathic normal pressure hydrocephalus. Show citation: Luciano MG, Williams MA, Hamilton MG, et al. A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus. N Engl J Med . 2025;393(22):2198-2209. doi: 10.1056/NEJMoa2503109 Show transcript: Dr. Margarita Fedorova: Welcome to Neurology Minute. My name is Margarita Fedorova and I'm a neurology resident at the Cleveland Clinic. Today we're reviewing a randomized trial that provides high quality evidence for treatment we've been using for decades, shunting for idiopathic normal pressure hydrocephalus. The PENS trial, a placebo controlled effectiveness and iNPH shunting trial was published in the New England Journal of Medicine in December 2025 by Luciano and colleagues. This international multicenter study enrolled 99 patients across the United States candidate in Sweden. While idiopathic normal pressure hydrocephalus or iNPH is characterized by triad of gait impairment, cognitive decline in urinary continence, these findings can be non-specific and we mass factor in radiological findings too. Furthermore, while CSF shunting has long been the standard treatment, its effectiveness has never been rigorously confirmed in a large well-powered randomized trial. In this trial, patients with a clinical improvement in gait velocity after temporary CSF drainage were deemed eligible for shunting and randomizing the trial. What makes this trial particularly elegant is its blending strategy. All 99 participants underwent the same surgical procedure with the same commercially available programmable shunt valve. After surgery, the valve was set either to an open functioning position or to a high resistance placebo setting. Neither patients nor assess…","meta_description":"Dr. Margarita Fedorova discusses the effectiveness of shunting for idiopathic normal pressure hydrocephalus. Show citation: Luciano MG, Williams MA, Hamil…","key_points":[],"chapters":[],"topics":[],"duration_seconds":205,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/neurology-minute-15117/episodes/shunting-for-idiopathic-normal-pressure-hydrocephalus/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/neurology-minute-15117/shunting-for-idiopathic-normal-pressure-hydrocephalus.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}