{"podcast":{"title":"Mikkipedia","slug":"mikkipedia-1319728","podcast_index_feed_id":1319728,"rss_url":"https://feeds.transistor.fm/mikkipedia","website_url":"https://www.mikkiwilliden.com","image_url":"https://img.transistorcdn.com/Rex5xizm5s75WEApb0hW2pnxZ3-n21cWTFT6Emw0820/rs:fill:0:0:1/w:1400/h:1400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8wNjI2/NTEwMjAyMWQ2M2Iy/ZjliYjA4ZGFhMTBh/N2E2Ni5qcGc.jpg","author":"Mikki Williden","episode_count":502,"summary":"Mikkipedia is an exploration in all things health, well being, fitness, food and nutrition. I sit down with scientists, doctors, professors, practitioners and people who have a wealth of experience and have a conversation that takes a deep dive into their area of expertise. I love translating science into a language that people understand, so while some of the conversations will be pretty in-depth, you will come away with some practical tips that can be instigated into your everyday life. I hope you enjoy the show!","last_synced_at":"2026-09-13T20:21:17.966335+00:00","page_url":"https://stenobird.com/podcast/mikkipedia-1319728"},"episode":{"title":"Mini Mikkipedia - When GLP-1 Weight Loss Dims Motivation","slug":"mini-mikkipedia-when-glp-1-weight-loss-dims-motivation","published_at":"2026-07-19T17:00:00+00:00","page_url":"https://stenobird.com/podcast/mikkipedia-1319728/mini-mikkipedia-when-glp-1-weight-loss-dims-motivation","show_page_url":"https://stenobird.com/podcast/mikkipedia-1319728","url":"https://share.transistor.fm/s/7bc58860","audio_url":"https://media.transistor.fm/7bc58860/11e6aa5f.mp3","summary":"This episode explores emerging evidence that high-dose tirzepatide may reduce more than appetite and food noise in some people. Mikki breaks down a new case series involving three women who experienced anhedonia, a loss of motivation or interest in previously rewarding activities, despite achieving substantial weight loss. She explains the difference between “wanting” and “liking,” how GLP-1 medications may influence dopamine reward pathways, and why symptoms can feel different from depression or early medication side effects. The cases suggest that dose reduction may restore motivation without necessarily compromising weight-loss maintenance. While three cases cannot establish causation or prevalence, the findings highlight the importance of monitoring exercise, hobbies, social engagement, and overall enjoyment alongside weight, appetite, and gastrointestinal symptoms. Topics Covered What anhedonia is and how it differs from depression Three cases involving high-dose tirzepatide The potential role of dopamine and reward pathways Why dose reduction improved symptoms in these cases Practical considerations for patients and prescribers Contact Mikki: https://mikkiwilliden.com/ https://www.facebook.com/mikkiwillidennutrition https://www.instagram.com/mikkiwilliden/ https://linktr.ee/mikkiwilliden NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nz Save 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz , www.nuzest.com.au or www.nuzest.com Curranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order","meta_description":"This episode explores emerging evidence that high-dose tirzepatide may reduce more than appetite and food noise in some people. Mikki breaks down a new ca…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1337,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/mikkipedia-1319728/episodes/mini-mikkipedia-when-glp-1-weight-loss-dims-motivation/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/mikkipedia-1319728/mini-mikkipedia-when-glp-1-weight-loss-dims-motivation.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}