{"podcast":{"title":"Metabolic Mind","slug":"metabolic-mind-6253550","podcast_index_feed_id":6253550,"rss_url":"https://feeds.captivate.fm/metabolic-mind/","website_url":"https://metabolicmind.org/","image_url":"https://artwork.captivate.fm/d5c870fb-4d35-464f-8bde-33ce9e2b58c4/MM-Podcast-cover-final.png","author":"Bret Scher","episode_count":253,"summary":"Metabolic Mind is working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. Metabolic interventions like ketogenic therapy are being used to treat serious mental illnesses like Bipolar Disorder, Schizophrenia, and Major Depressive Disorder. We explore topics that can help you understand how Metabolic Psychiatry might help you or a loved one treat mental disorders Watch our videos at https://www.youtube.com/@metabolicmind Our channel is for information only. Consult your physician before changing your lifestyle or medications.","last_synced_at":"2026-09-29T14:20:16.643659+00:00","page_url":"https://stenobird.com/podcast/metabolic-mind-6253550"},"episode":{"title":"BITESIZE: New GLP-1 Study Raises Metabolic Health Questions","slug":"bitesize-new-glp-1-study-raises-metabolic-health-questions","published_at":"2026-08-13T14:40:00+00:00","page_url":"https://stenobird.com/podcast/metabolic-mind-6253550/bitesize-new-glp-1-study-raises-metabolic-health-questions","show_page_url":"https://stenobird.com/podcast/metabolic-mind-6253550","url":"https://metabolicmind.org/","audio_url":"https://episodes.captivate.fm/episode/78381495-424c-4aba-b19f-ed427fb92866.mp3","summary":"Do GLP-1 medications improve metabolic health as much as they support weight loss? A new observational study in the Annals of Internal Medicine raises an important question about semaglutide, insulin discontinuation, type 2 diabetes, and what meaningful metabolic improvement may require. In this episode of Metabolic Mind, Dr. Bret Scher breaks down a real-world study of more than 9,000 veterans with type 2 diabetes who were using insulin and then added either a GLP-1 receptor agonist, SGLT2 inhibitor, or DPP4 inhibitor. Despite semaglutide’s stronger association with weight loss, the study found similar insulin discontinuation rates across all three groups over three years. Dr. Scher covers: Why weight loss and metabolic health improvements may not always move together What insulin discontinuation can reveal about insulin resistance and beta cell function Why semaglutide did not outperform older diabetes medications in this study The limitations of observational research and real-world medication data How GLP-1 medications and therapeutic carbohydrate reduction may work through complementary mechanisms Why combining GLP-1s with therapeutic carbohydrate reduction may be an important area for future research and clinical practice This conversation takes a closer look at what metabolic health means, and why the path from weight loss to insulin independence may be more complex than the scale alone can show. 👉 Want to stay up to date with the latest research on metabolic health and metabolic psychiatry? Sign up for our newsletter to stay informed: metabolicmind.org/about-us/newsletter/ 🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode. #MetabolicMind #Ketogenic…","meta_description":"Do GLP-1 medications improve metabolic health as much as they support weight loss? A new observational study in the Annals of Internal Medicine raises an…","key_points":[],"chapters":[],"topics":[],"duration_seconds":325,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/metabolic-mind-6253550/episodes/bitesize-new-glp-1-study-raises-metabolic-health-questions/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/metabolic-mind-6253550/bitesize-new-glp-1-study-raises-metabolic-health-questions.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}