{"podcast":{"title":"Machine Learning Street Talk (MLST)","slug":"machine-learning-street-talk","podcast_index_feed_id":781643,"rss_url":"https://anchor.fm/s/1e4a0eac/podcast/rss","website_url":"https://podcasters.spotify.com/pod/show/machinelearningstreettalk","image_url":"https://d3t3ozftmdmh3i.cloudfront.net/staging/podcast_uploaded_nologo/4981699/4981699-1757416025703-f026fa81b6d04.jpg","author":"Machine Learning Street Talk (MLST)","episode_count":254,"summary":"Welcome! We engage in fascinating discussions with pre-eminent figures in the AI field. Our flagship show covers current affairs in AI, cognitive science, neuroscience and philosophy of mind with in-depth analysis. Our approach is unrivalled in terms of scope and rigour – we believe in intellectual diversity in AI, and we touch on all of the main ideas in the field with the hype surgically removed. MLST is run by Tim Scarfe, Ph.D (https://www.linkedin.com/in/ecsquizor/) and features regular appearances from MIT Doctor of Philosophy Keith Duggar (https://www.linkedin.com/in/dr-keith-duggar/).","last_synced_at":"2026-06-29T06:18:19.444379+00:00","page_url":"https://stenobird.com/podcast/machine-learning-street-talk"},"episode":{"title":"He won a Nobel here for AlphaFold. Then he left. - John Jumper","slug":"he-won-a-nobel-here-for-alphafold-then-he-left-john-jumper","published_at":"2026-06-22T22:49:31+00:00","page_url":"https://stenobird.com/podcast/machine-learning-street-talk/he-won-a-nobel-here-for-alphafold-then-he-left-john-jumper","show_page_url":"https://stenobird.com/podcast/machine-learning-street-talk","url":"https://podcasters.spotify.com/pod/show/machinelearningstreettalk/episodes/He-won-a-Nobel-here-for-AlphaFold--Then-he-left----John-Jumper-e3l579p","audio_url":"https://traffic.megaphone.fm/APO2063042132.mp3","summary":"This episode is sponsored by Notion. Learn more about Notion's Developer Platform today at https://notion.com/mlstProtein folding stalled biology for fifty years. A sequence of amino acids dictates a three-dimensional shape, but reading that shape meant a year and roughly $100,000 of crystallography per structure. Then AlphaFold 2 won CASP14 so decisively the organizers called the problem essentially solved.In this documentary cut, John Jumper, who shared the 2024 Nobel Prize in Chemistry and has since left DeepMind for Anthropic, walks Tim Scarfe through what the system did and, more interestingly, what it did not. The architecture gets a proper dissection: MSAs, the Evoformer, invariant point attention, the FAPE loss, and Jumper's correction of the equivariance story, which ablations valued at roughly 2.5 of 30 GDT points rather than the whole win. He is blunt about the limits. AlphaFold predicts one experiment extraordinarily well; it is not a model of the cell, it does not capture dynamics, and on a given drug target it is "wrong nine times out of ten."From there: the AlphaFold Database of 200M+ predicted structures, AlphaFold 3 and ligands, Isomorphic Labs, and Jumper's quarrel with the bitter lesson, where finite data and human hypotheses still matter. Emmanuel Nji of BioStruct Africa closes the film on what changes when work that took years now takes months, and on training the next thousand structural biologists across Africa.---TIMESTAMPS:00:00:00 Cold open: predicting nature with a button press00:01:03 The protein folding bottleneck and CASP00:04:39 The Nobel, the database, and the move to Anthropic00:05:50 Sponsor (Notion) and framing: what AlphaFold does not claim00:07:39 Proteins as self-assembling nanomachines00:12:24 From structures to biology:…","meta_description":"This episode is sponsored by Notion. Learn more about Notion's Developer Platform today at https://notion.com/mlstProtein folding stalled biology for fift…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3185,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/machine-learning-street-talk/episodes/he-won-a-nobel-here-for-alphafold-then-he-left-john-jumper/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/machine-learning-street-talk/he-won-a-nobel-here-for-alphafold-then-he-left-john-jumper.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}