{"podcast":{"title":"LONGEVITY with Nathalie Niddam","slug":"longevity-with-nathalie-niddam-1367436","podcast_index_feed_id":1367436,"rss_url":"https://rss2.flightcast.com/zuvawsnkkxtbynwgy0632z94.xml","website_url":"https://www.nathalieniddam.com/","image_url":"https://assets.flightcast.com/workspaces/fo0ip1v9e014oduot5kqgdle/podcasts/zuvawsnkkxtbynwgy0632z94/ambje8j39z9hs4bf0r3u5udm.png","author":"Nathalie Niddam","episode_count":446,"summary":"LONGEVITY with Nathalie Niddam is your go-to podcast for diving deep into the science and practices for increasing your longevity and healthspan. This podcast covers topics from nutrition, biohacking, longevity, peptides, bioregulators, cutting edge research, health technology and more! Nathalie Niddam is a certified nutritionist, as well as a epigenetics and human potential coach.","last_synced_at":"2026-06-26T18:17:14.148729+00:00","page_url":"https://stenobird.com/podcast/longevity-with-nathalie-niddam-1367436"},"episode":{"title":"#439: Reclaiming Metabolism: The SECRET Molecule Transforming Women's Health (Belly Fat, Brain Power & Beyond) With Siobhan Mitchell PhD","slug":"439-reclaiming-metabolism-the-secret-molecule-transforming-women-s-health-belly-fat-brain-power-beyond-with-siobhan-mitchell-phd","published_at":"2026-05-19T11:51:00+00:00","page_url":"https://stenobird.com/podcast/longevity-with-nathalie-niddam-1367436/439-reclaiming-metabolism-the-secret-molecule-transforming-women-s-health-belly-fat-brain-power-beyond-with-siobhan-mitchell-phd","show_page_url":"https://stenobird.com/podcast/longevity-with-nathalie-niddam-1367436","url":"https://episode.flightcast.com/01KRGGSRME51W0X9X52KQ4Z6FZ.mp3","audio_url":"https://episode.flightcast.com/01KRGGSRME51W0X9X52KQ4Z6FZ.mp3","summary":"Today, I’m joined by the insightful Siobhan Mitchell PhD, a leading expert on women’s health, mitochondria, and metabolic resilience. In our conversation, Siobhan reveals why so many women in their 30s and 40s feel like their metabolism is suddenly “broken,” and unpacks the real science behind what’s happening beneath the surface—especially as our hormones begin to shift. Episode Timestamps: Introduction and host welcome ... 00:00:00 Introducing Speaker B and focus on women’s health ... 00:04:30 Growing interest in women’s health and clinical gaps ... 00:05:12 Body composition and metabolic changes in perimenopause ... 00:06:01 Hormonal shifts—not a broken metabolism ... 00:09:21 Addressing the root cause versus band-aids like GLP-1 ... 00:11:10 What’s happening beneath the surface in early perimenopause ... 00:12:40 Role of estrogen in appetite, glucose, and fat storage ... 00:13:12 Visceral fat, inflammation, and accelerated aging ... 00:15:02 Estrogen’s connection to mitochondrial function ... 00:16:15 Brain, muscle, and cognitive declines with estrogen loss ... 00:16:44 Environmental and mitochondrial factors in PCOS ... 00:21:09 Shift to belly fat and why fat storage changes ... 00:22:58 Mitochondria, immune system, and autoimmunity in women ... 00:29:16 Phytoestrogens, soy, and S-equol as hormone alternatives ... 00:32:37 S-equol’s benefits: metabolic, bone, and brain health ... 00:35:50 Soy fears, GMOs, and the purity of S-equol ... 00:46:25 Microbiome, Bifidobacterium breve, and estrogen recycling ... 00:49:18 GLP-1s versus supporting the root cause ... 00:53:01 Optimizing estrogen signaling for health span and menopause timing ... 00:55:20 When to use S-equol: timing and benefits ... 00:55:54 Reversing visceral fat and lifestyle factors ... 01:03:28 Our Amazin…","meta_description":"Today, I’m joined by the insightful Siobhan Mitchell PhD, a leading expert on women’s health, mitochondria, and metabolic resilience. In our conversation,…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3965,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/longevity-with-nathalie-niddam-1367436/episodes/439-reclaiming-metabolism-the-secret-molecule-transforming-women-s-health-belly-fat-brain-power-beyond-with-siobhan-mitchell-phd/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/longevity-with-nathalie-niddam-1367436/439-reclaiming-metabolism-the-secret-molecule-transforming-women-s-health-belly-fat-brain-power-beyond-with-siobhan-mitchell-phd.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}