{"podcast":{"title":"Ion Genomics Podcast","slug":"ion-genomics-podcast-7831901","podcast_index_feed_id":7831901,"rss_url":"https://api.riverside.com/hosting/bjJ8IM8g.rss","website_url":"www.iongenomics.bio","image_url":"https://hosting-media.riverside.com/media/podcasts/33a5b670-e982-44e8-9d9e-9861ff1bad6b/logos/36dbc099-5e7f-409e-9b79-08546d4716e4.png","author":"Andrew P. Han","episode_count":13,"summary":"Ion Genomics brings you in-depth but also wide-ranging conversations with leading figures in genomic science and technology. Hosted by veteran science journalist Andrew P. Han, the Ion Genomics Podcast is a weekly window into the latest advances driving exploration of human biology. For more science and business news, check out www.iongenomics.bio and subscribe to the newsletter.","last_synced_at":"2026-09-26T00:18:21.685943+00:00","page_url":"https://stenobird.com/podcast/ion-genomics-podcast-7831901"},"episode":{"title":"How to Wiretap a Billion Cells, with Dino Di Carlo","slug":"how-to-wiretap-a-billion-cells-with-dino-di-carlo","published_at":"2026-07-24T07:00:00+00:00","page_url":"https://stenobird.com/podcast/ion-genomics-podcast-7831901/how-to-wiretap-a-billion-cells-with-dino-di-carlo","show_page_url":"https://stenobird.com/podcast/ion-genomics-podcast-7831901","url":"https://api.riverside.com/hosting-analytics/media/a41e17d157ea059373de3f75a73439612b14e92af610a26fb2195a3b9a9244f4/eyJlcGlzb2RlSWQiOiI3ZWYyZWE2NC02ZWRhLTRkZWMtYmM5Ni03MzdhYzA0NDdlNzEiLCJwb2RjYXN0SWQiOiIzM2E1YjY3MC1lOTgyLTQ0ZTgtOWQ5ZS05ODYxZmYxYmFkNmIiLCJhY2NvdW50SWQiOiI2OWIzMTk0ZDExZTc3MTlhNjFmZmRmNTYiLCJwYXRoIjoibWVkaWEvY2xpcHMvNmE2MjhhNTIyMGE4MzhhNDhhMjVmMmJhL2FuZHJldy1oYW5zLXN0dWRpby1HZ25NUy1jb21wb3Nlci0yMDI2LTctMjNfXzIzLTQwLTMzLm1wMyJ9.mp3","audio_url":"https://api.riverside.com/hosting-analytics/media/a41e17d157ea059373de3f75a73439612b14e92af610a26fb2195a3b9a9244f4/eyJlcGlzb2RlSWQiOiI3ZWYyZWE2NC02ZWRhLTRkZWMtYmM5Ni03MzdhYzA0NDdlNzEiLCJwb2RjYXN0SWQiOiIzM2E1YjY3MC1lOTgyLTQ0ZTgtOWQ5ZS05ODYxZmYxYmFkNmIiLCJhY2NvdW50SWQiOiI2OWIzMTk0ZDExZTc3MTlhNjFmZmRmNTYiLCJwYXRoIjoibWVkaWEvY2xpcHMvNmE2MjhhNTIyMGE4MzhhNDhhMjVmMmJhL2FuZHJldy1oYW5zLXN0dWRpby1HZ25NUy1jb21wb3Nlci0yMDI2LTctMjNfXzIzLTQwLTMzLm1wMyJ9.mp3","summary":"What happens when scientists come together and realize they didn’t have the data to back up their assumptions? Dino Di Carlo, my guest on this week’s Ion Genomics podcast, shares how he reacted when he found out that there were huge gaps in understanding how individual cells communicate with each other. To remedy this, he has proposed a project to analyze a billion cells, largely in two-cell dyads. He published a paper outlining his vision in Nature Biotechnology. His idea leverages two sequencing technologies. One is proximity sequencing (Prox-seq) , a method developed at the University of Chicago that offers information on proteins near each other on top of standard single-cell transcriptomics. Another, developed in Di Carlo’s lab and being commercialized by a company he cofounded, is nanovials , a cell capture method that enables the analysis of cell dyads using popular single-cell sequencing techniques. The tech is being commericalized by Partillion Bioscience, a company Di Carlo cofounded. Di Carlo spoke to me from Japan, where he’s spending the summer setting up a satellite lab, in large part to find stability after he was denied access to grant funding his lab had been awarded as part of the Trump Administration’s conflict with major research universities. Stay tuned to the end for his recommendations on the most underrated sushi types on the menu.","meta_description":"What happens when scientists come together and realize they didn’t have the data to back up their assumptions? Dino Di Carlo, my guest on this week’s Ion…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2797,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/ion-genomics-podcast-7831901/episodes/how-to-wiretap-a-billion-cells-with-dino-di-carlo/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/ion-genomics-podcast-7831901/how-to-wiretap-a-billion-cells-with-dino-di-carlo.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}