{"podcast":{"title":"In the Interim...","slug":"in-the-interim-7211889","podcast_index_feed_id":7211889,"rss_url":"https://feeds.transistor.fm/in-the-interim","website_url":"https://berryconsultants.com","image_url":"https://img.transistorcdn.com/4kEBoJ9pC_kLNSr6AX2uD_qdxx8BJ7dMddtvubROpQ0/rs:fill:0:0:1/w:1400/h:1400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9jM2M0/ZDE2YzA1N2FhNjkx/NDk1NDczNjYzM2E5/NjlmYS5wbmc.jpg","author":"Berry","episode_count":66,"summary":"A podcast on statistical science and clinical trials. Explore the intricacies of Bayesian statistics and adaptive clinical trials. Uncover methods that push beyond conventional paradigms, ushering in data-driven insights that enhance trial outcomes while ensuring safety and efficacy. Join us as we dive into complex medical challenges and regulatory landscapes, offering innovative solutions tailored for pharma pioneers. Featuring expertise from industry leaders, each episode is crafted to provide clarity, foster debate, and challenge mainstream perspectives, ensuring you remain at the forefront of clinical trial excellence.","last_synced_at":"2026-06-16T00:19:29.083980+00:00","page_url":"https://stenobird.com/podcast/in-the-interim-7211889"},"episode":{"title":"Platform Trial in Orthopaedic Surgery","slug":"platform-trial-in-orthopaedic-surgery","published_at":"2026-02-09T12:00:00+00:00","page_url":"https://stenobird.com/podcast/in-the-interim-7211889/platform-trial-in-orthopaedic-surgery","show_page_url":"https://stenobird.com/podcast/in-the-interim-7211889","url":"https://share.transistor.fm/s/bc017223","audio_url":"https://media.transistor.fm/bc017223/55465374.mp3","summary":"Dr. Nathan O’Hara (University of Maryland), Dr. Gerard Slobogean (UC Irvine), and Dr. Sheila Sprague (McMaster University) describe the launch and design of the Musculoskeletal Adaptive Platform Trial (MAPT)—the first major adaptive platform trial in orthopaedic surgery. The discussion covers MAPT’s master protocol structure, patient-centered endpoint framework, and operational strategies for multinational implementation. Focus areas include the FASTER-HIP domain’s use of Bayesian modeling with a hierarchical clinical endpoint and the standards established for adaptation, data coordination, and future scalability. Listeners gain insight into a trial infrastructure designed to lower barriers for evidence generation and facilitate ongoing evidence generation in musculoskeletal trauma care. Key Highlights MAPT as a scalable, master protocol for orthopaedic intervention evaluation Hierarchical, patient-centered endpoint (survival, 4-level ambulation, days alive/out of hospital), analyzed with a Bayesian-modeled, non-parametric win ratio Domain-specific adaptation thresholds based on clinical differentiation Interim analyses after 100 patients, then every 50, informing early adaptation 40 sites across US, Canada, and Europe, centralized data management at McMaster A unified DSMB structure with capacity for domain-specific expertise as needed Tiered protocol access: open sharing, collaboration, direct integration Infrastructure enables rapid domain addition and multi-investigator participation For more, visit us at https://www.berryconsultants.com/","meta_description":"Dr. Nathan O’Hara (University of Maryland), Dr. Gerard Slobogean (UC Irvine), and Dr. Sheila Sprague (McMaster University) describe the launch and design…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2456,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/in-the-interim-7211889/episodes/platform-trial-in-orthopaedic-surgery/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/in-the-interim-7211889/platform-trial-in-orthopaedic-surgery.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}