{"podcast":{"title":"In the Interim...","slug":"in-the-interim-7211889","podcast_index_feed_id":7211889,"rss_url":"https://feeds.transistor.fm/in-the-interim","website_url":"https://berryconsultants.com","image_url":"https://img.transistorcdn.com/4kEBoJ9pC_kLNSr6AX2uD_qdxx8BJ7dMddtvubROpQ0/rs:fill:0:0:1/w:1400/h:1400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9jM2M0/ZDE2YzA1N2FhNjkx/NDk1NDczNjYzM2E5/NjlmYS5wbmc.jpg","author":"Berry","episode_count":77,"summary":"A podcast on statistical science and clinical trials. Explore the intricacies of Bayesian statistics and adaptive clinical trials. Uncover methods that push beyond conventional paradigms, ushering in data-driven insights that enhance trial outcomes while ensuring safety and efficacy. Join us as we dive into complex medical challenges and regulatory landscapes, offering innovative solutions tailored for pharma pioneers. Featuring expertise from industry leaders, each episode is crafted to provide clarity, foster debate, and challenge mainstream perspectives, ensuring you remain at the forefront of clinical trial excellence.","last_synced_at":"2026-09-08T00:17:11.625653+00:00","page_url":"https://stenobird.com/podcast/in-the-interim-7211889"},"episode":{"title":"ICECAP: The Results","slug":"icecap-the-results","published_at":"2026-08-05T17:27:49+00:00","page_url":"https://stenobird.com/podcast/in-the-interim-7211889/icecap-the-results","show_page_url":"https://stenobird.com/podcast/in-the-interim-7211889","url":"https://share.transistor.fm/s/10d25d52","audio_url":"https://media.transistor.fm/10d25d52/182f2d62.mp3","summary":"In this episode of \"In the Interim…\", Dr. Scott Berry leads a comprehensive discussion of the ICECAP trial results with four Principal Investigators: Dr. Will Meurer (Professor, Emergency Medicine and Neurology, University of Michigan; consultant to Berry Consultants), Dr. Robert Silbergleit (Professor, Emergency Medicine, University of Michigan Medical School), Dr. Romer Geocadin (Professor, Neurology, Neurosurgery, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine), and Dr. Sharon Yeatts (Professor of Biostatistics, Public Health Sciences, Medical University of South Carolina). The panel dissects the ICECAP trial’s multi-arm Bayesian adaptive design, response-adaptive randomization, and population-level approach to cooling duration after out-of-hospital cardiac arrest. Emphasis is placed on methodological transparency, direct operational experience, absence of evidence for incremental benefit beyond six hours of cooling, and future direction for neurocritical care trials. Key Highlights Detailed review of adaptive design methodology, Bayesian interim analyses, and stopping criteria for futility based on posterior probabilities Analysis of flat duration-response curve: no clinical benefit seen for extended hypothermia, trial triggered to stop per prespecified rule Cohort discussion: representation of U.S. epidemiology, inclusion of heterogeneous etiologies (notably respiratory and overdose) and bystander CPR rates Operational challenges: running frequent interim analyses, maintaining trial integrity during COVID-19, site-level differences, statistical reporting timelines Panel consensus on the need for continued equipoise in temperature management, caution against misinterpretation, and priority for precision subgroups in futur…","meta_description":"In this episode of \"In the Interim…\", Dr. Scott Berry leads a comprehensive discussion of the ICECAP trial results with four Principal Investigators: Dr.…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3282,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/in-the-interim-7211889/episodes/icecap-the-results/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/in-the-interim-7211889/icecap-the-results.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}