{"podcast":{"title":"Health Optimization Medicine Podcast","slug":"health-optimization-medicine-podcast-5954129","podcast_index_feed_id":5954129,"rss_url":"https://feeds.libsyn.com/454677/rss","website_url":"https://sites.libsyn.com/454677","image_url":"https://static.libsyn.com/p/assets/3/0/2/b/302b19774bea706416c3140a3186d450/HOMe_Podcast_-_Libsyn.png","author":"Health Optimization Medicine and Practice","episode_count":185,"summary":"The Health Optimization Medicine Podcast is dedicated to offering one-cent solutions to life's $64,000 questions across health optimization, decision-making, consciousness, performance, and human potential. Produced by Health Optimization Medicine & Practice (HOMeHOPe) and Smarter Not Harder, Inc., the makers of Troscriptions, this podcast bridges rigorous science with real-world clinical application. Each episode features in-depth conversations with leading researchers, clinicians, and original thinkers, including Karl Friston, Donald Hoffman, Anna Lembke, Adam Robinson, and Dominic D'Agostino. Together, they explore how small, precise interventions can create meaningful and lasting impact. Hosted by: + Dr. Ted Achacoso, founding pioneer of HOMeHOPe and Smarter Not Harder, Inc. + Dr. Scott Sherr, COO of HOMeHOPe and Smarter Not Harder, Inc. + Boomer Anderson, CEO of HOMeHOPe and Smarter Not Harder, Inc. + Jodi Duval, principal naturopath, formulator at Revital Health in Perth, Australia, and CEO of HOMeHOPe Australia New episodes every Wednesday. Previously published as the Smarter Not Harder Podcast (SNH Podcast).","last_synced_at":"2026-07-23T06:18:33.154681+00:00","page_url":"https://stenobird.com/podcast/health-optimization-medicine-podcast-5954129"},"episode":{"title":"Microglia, Metabolism & the Future of Brain Health | HOMe Podcast #005","slug":"microglia-metabolism-the-future-of-brain-health-home-podcast-005","published_at":"2026-04-08T15:30:00+00:00","page_url":"https://stenobird.com/podcast/health-optimization-medicine-podcast-5954129/microglia-metabolism-the-future-of-brain-health-home-podcast-005","show_page_url":"https://stenobird.com/podcast/health-optimization-medicine-podcast-5954129","url":"https://672d8edf-a640-45ce-ac61-cd5f898a7b27.libsyn.com/microglia-metabolism-the-future-of-brain-health-home-podcast-005","audio_url":"https://traffic.libsyn.com/secure/672d8edf-a640-45ce-ac61-cd5f898a7b27/HOMe_005-AUDIO.mp3?dest-id=3824325","summary":"In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more. Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience. Join us as we delve into: What microglia are and why they control brain health The difference between M1 (destructive) and M2 (protective) states How metabolism shapes the brain's immune response Why conditions like Alzheimer's are rooted in immune dysfunction The connection between blood sugar, insulin, and brain degeneration This episode is for you if: You want to protect your brain and prevent cognitive decline You're interested in the science of Alzheimer's and neurodegeneration You want actionable strategies to improve brain health You're curious about the future of brain optimization and longevity You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/ Find more from Health Optimization Medicine and…","meta_description":"In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3540,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/health-optimization-medicine-podcast-5954129/episodes/microglia-metabolism-the-future-of-brain-health-home-podcast-005/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/health-optimization-medicine-podcast-5954129/microglia-metabolism-the-future-of-brain-health-home-podcast-005.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}