{"podcast":{"title":"Health Optimization Medicine Podcast","slug":"health-optimization-medicine-podcast-5954129","podcast_index_feed_id":5954129,"rss_url":"https://feeds.libsyn.com/454677/rss","website_url":"https://sites.libsyn.com/454677","image_url":"https://static.libsyn.com/p/assets/3/0/2/b/302b19774bea706416c3140a3186d450/HOMe_Podcast_-_Libsyn.png","author":"Health Optimization Medicine and Practice","episode_count":185,"summary":"The Health Optimization Medicine Podcast is dedicated to offering one-cent solutions to life's $64,000 questions across health optimization, decision-making, consciousness, performance, and human potential. Produced by Health Optimization Medicine & Practice (HOMeHOPe) and Smarter Not Harder, Inc., the makers of Troscriptions, this podcast bridges rigorous science with real-world clinical application. Each episode features in-depth conversations with leading researchers, clinicians, and original thinkers, including Karl Friston, Donald Hoffman, Anna Lembke, Adam Robinson, and Dominic D'Agostino. Together, they explore how small, precise interventions can create meaningful and lasting impact. Hosted by: + Dr. Ted Achacoso, founding pioneer of HOMeHOPe and Smarter Not Harder, Inc. + Dr. Scott Sherr, COO of HOMeHOPe and Smarter Not Harder, Inc. + Boomer Anderson, CEO of HOMeHOPe and Smarter Not Harder, Inc. + Jodi Duval, principal naturopath, formulator at Revital Health in Perth, Australia, and CEO of HOMeHOPe Australia New episodes every Wednesday. Previously published as the Smarter Not Harder Podcast (SNH Podcast).","last_synced_at":"2026-07-23T06:18:33.154681+00:00","page_url":"https://stenobird.com/podcast/health-optimization-medicine-podcast-5954129"},"episode":{"title":"Decoding the Holobiont: The Ecosystem of Ecosystems | HOMe Podcast Special Episode","slug":"decoding-the-holobiont-the-ecosystem-of-ecosystems-home-podcast-special-episode","published_at":"2026-06-24T16:05:00+00:00","page_url":"https://stenobird.com/podcast/health-optimization-medicine-podcast-5954129/decoding-the-holobiont-the-ecosystem-of-ecosystems-home-podcast-special-episode","show_page_url":"https://stenobird.com/podcast/health-optimization-medicine-podcast-5954129","url":"https://672d8edf-a640-45ce-ac61-cd5f898a7b27.libsyn.com/decoding-the-holobiont-the-ecosystem-of-ecosystems-home-podcast-special-episode","audio_url":"https://traffic.libsyn.com/secure/672d8edf-a640-45ce-ac61-cd5f898a7b27/HOMe_Podcast_Special_Ep_001.mp3?dest-id=3824325","summary":"In this special in-person roundtable recorded in Washington, D.C., the HOMeHOPe faculty sit down to decode one of the most important perspective shifts in modern health: the Holobiont. Moving away from the traditional, siloed medical model of \"organology\" (treating the heart, gut, and brain as isolated systems managed by different specialists), the faculty discusses why true health optimization requires viewing the human body as a complex, interconnected ecosystem of ecosystems. Join us as we delve into: The Holobiont Paradigm: Why you are not just a single organism, but a super-ecosystem made up of human cells and trillions of cooperating microbiota (including in your cornea, ureters, and gut). The Danger of \"Organ\" Medicine: How specializing solely in individual organs leads to clinical blind spots, and why common prescriptions like statins and PPIs can quietly disrupt cellular energy (CoQ10) and nutrient absorption system-wide. Metabolomics vs. Genetics: Why your DNA only tells you what might happen, while clinical metabolomics tells you exactly what is happening right now. The Cell Danger Response (CDR): How your metabolites act as powerful epigenetic signalers, turning genes on and off to regulate systemic health and recovery. The N-of-1 Future: Why large randomized controlled trials (RCTs) often fail by completely ignoring the gut microbiome, and why personalized, N-of-1 medicine is the only true path forward. This episode is for you if: You are tired of being bounced between specialists for interconnected symptoms like mood disturbances, fatigue, and chronic bloating. You want to understand the limitations of DNA testing and why measuring real-time metabolites is the gold standard for biohacking. You are a clinician looking to shift your practice from illness ma…","meta_description":"In this special in-person roundtable recorded in Washington, D.C., the HOMeHOPe faculty sit down to decode one of the most important perspective shifts in…","key_points":[],"chapters":[],"topics":[],"duration_seconds":928,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/health-optimization-medicine-podcast-5954129/episodes/decoding-the-holobiont-the-ecosystem-of-ecosystems-home-podcast-special-episode/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/health-optimization-medicine-podcast-5954129/decoding-the-holobiont-the-ecosystem-of-ecosystems-home-podcast-special-episode.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}