{"podcast":{"title":"HCPLive Podcasts","slug":"hcplive-podcasts-19526","podcast_index_feed_id":19526,"rss_url":"https://audioboom.com/channels/5004077.rss","website_url":"https://audioboom.com/channels/5004077","image_url":"https://audioboom.com/i/40144427.png","author":"HCPLive.com","episode_count":243,"summary":"Your destination feed for medical, health care and clinical science podcasts courtesy of HCPLive—featuring our shows Medical Ethics Unpacked, New Insight, and 5 Stories in Under 5.","last_synced_at":null,"page_url":"https://stenobird.com/podcast/hcplive-podcasts-19526"},"episode":{"title":"Liver Lineup: GLP-1 RAs and FGF21s for MASH, with Mary Rinella, MD","slug":"liver-lineup-glp-1-ras-and-fgf21s-for-mash-with-mary-rinella-md","published_at":"2026-02-03T21:43:38+00:00","page_url":"https://stenobird.com/podcast/hcplive-podcasts-19526/liver-lineup-glp-1-ras-and-fgf21s-for-mash-with-mary-rinella-md","show_page_url":"https://stenobird.com/podcast/hcplive-podcasts-19526","url":"https://audioboom.com/posts/8856583","audio_url":"https://audioboom.com/posts/8856583.mp3?modified=1770155093&sid=5004077&source=rss","summary":"In this episode of Liver Lineup: Updates and Unfiltered Insights , hosts Nancy Reau, MD, and Kimberly Brown, MD, sit down with Mary (Maru) Rinella, MD, a professor of medicine and director of Clinical Trials and the Metabolic and Fatty Liver Program at the University of Chicago, to discuss the rapidly evolving therapeutic landscape for metabolic dysfunction-associated steatohepatitis (MASH). Key Episode Timestamps: 0:00:00 – Introduction & guest bio 0:01:02 – Current therapy landscape & GLP‑1 overview 0:03:51 – Do GLP‑1s help non–weight losers? 0:05:21 – Combining GLP‑1s and resmetirom 0:07:23 – Pipeline GLP‑1 combinations & phase 2 data 0:09:26 – Advanced disease, sarcopenia & risk–benefit in cirrhosis 0:13:29 – Introduction to FGF‑21 agonists 0:14:04 – Symmetry (efruxifermin) trial & reading the data 0:17:51 – Endpoints, “lack of progression,” and FDA hurdles 0:19:41 – Need for non‑invasive surrogates 0:21:02 – FGF‑21 mechanism & other liver diseases 0:22:57 – Alcohol intake, GLP‑1s, FGF‑21 & MetALD 0:25:49 – 10‑year outlook & future toolbox 0:27:35 – Closing","meta_description":"In this episode of Liver Lineup: Updates and Unfiltered Insights , hosts Nancy Reau, MD, and Kimberly Brown, MD, sit down with Mary (Maru) Rinella, MD, a…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1676,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/hcplive-podcasts-19526/episodes/liver-lineup-glp-1-ras-and-fgf21s-for-mash-with-mary-rinella-md/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/hcplive-podcasts-19526/liver-lineup-glp-1-ras-and-fgf21s-for-mash-with-mary-rinella-md.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}