{"podcast":{"title":"HCPLive Podcasts","slug":"hcplive-podcasts-19526","podcast_index_feed_id":19526,"rss_url":"https://audioboom.com/channels/5004077.rss","website_url":"https://audioboom.com/channels/5004077","image_url":"https://audioboom.com/i/40144427.png","author":"HCPLive.com","episode_count":243,"summary":"Your destination feed for medical, health care and clinical science podcasts courtesy of HCPLive—featuring our shows Medical Ethics Unpacked, New Insight, and 5 Stories in Under 5.","last_synced_at":null,"page_url":"https://stenobird.com/podcast/hcplive-podcasts-19526"},"episode":{"title":"Liver Lineup: Breakthroughs in Cholestatic Liver Disease in 2025","slug":"liver-lineup-breakthroughs-in-cholestatic-liver-disease-in-2025","published_at":"2026-02-04T14:12:11+00:00","page_url":"https://stenobird.com/podcast/hcplive-podcasts-19526/liver-lineup-breakthroughs-in-cholestatic-liver-disease-in-2025","show_page_url":"https://stenobird.com/podcast/hcplive-podcasts-19526","url":"https://audioboom.com/posts/8856829","audio_url":"https://audioboom.com/posts/8856829.mp3?modified=1770214440&sid=5004077&source=rss","summary":"In this special edition episode of Liver Lineup , recorded as part of HCPLive's This Year in Medicine series , hosts Nancy Reau, MD, and Kimberly Brown, MD, break down the most consequential updates of the year across primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH), highlighting data that may reshape both near-term management and longer-term treatment strategies. Key episode timestamps: 0:00:00 – Intro 0:00:40 – Underuse of second‑line therapy in PBC 0:03:40 – Long‑term data on PPAR agonists (elafibranor, seladelpar) in PBC 0:09:35 – PSC: elafibranor (Elmwood trial) and CCL24 mAb (nabokitug) 0:15:56 – Cholestasis symptoms: fatigue and pruritus and PPAR impact 0:20:20 – Autoimmune hepatitis: limitations of current therapy; new agent","meta_description":"In this special edition episode of Liver Lineup , recorded as part of HCPLive's This Year in Medicine series , hosts Nancy Reau, MD, and Kimberly Brown, M…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1514,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/hcplive-podcasts-19526/episodes/liver-lineup-breakthroughs-in-cholestatic-liver-disease-in-2025/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/hcplive-podcasts-19526/liver-lineup-breakthroughs-in-cholestatic-liver-disease-in-2025.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}