{"podcast":{"title":"Galaxy Balance","slug":"galaxy-balance-7619530","podcast_index_feed_id":7619530,"rss_url":"https://api.riverside.fm/hosting/TsNBRv3G.rss","website_url":"https://riverside.com","image_url":"https://hosting-media.riverside.com/media/podcasts/c0a4b47b-b2c9-4c68-88b5-1baa3a352c83/logos/0081482a-5241-4cdc-aa4f-c89d3aca95e7.png","author":"Cory Smith","episode_count":20,"summary":"Galaxy Balance explores the frontier where biology, technology and consciousness meet. Each episode brings together pioneers shaping our collective future, from genome engineers and AI builders to longevity researchers, space explorers, and mindfulness practitioners. Hosted by Cory Smith, the conversations dive deep into how these seemingly distant fields form an interconnected ecosystem, one that balance innovation with introspection, science with spirit, and ambition with awareness. At its core, Galaxy Balance is about integration; the idea that our greatest leaps forward happen when disciplines collide. The same algorithms that decode galaxies can help us understand genomes; the same principles that govern consciousness can illuminate AI. Through long-form, unscripted dialogue, the show invites listeners to zoom out from the silos of specialization and see the larger pattern: a living system of intelligence evolving across scales – molecular, planetary, and cosmic.","last_synced_at":null,"page_url":"https://stenobird.com/podcast/galaxy-balance-7619530"},"episode":{"title":"Marc Güell: AI, Synthetic Evolution, and the Future of Genome Engineering","slug":"marc-g-ell-ai-synthetic-evolution-and-the-future-of-genome-engineering","published_at":"2026-03-10T00:54:44+00:00","page_url":"https://stenobird.com/podcast/galaxy-balance-7619530/marc-g-ell-ai-synthetic-evolution-and-the-future-of-genome-engineering","show_page_url":"https://stenobird.com/podcast/galaxy-balance-7619530","url":"https://api.riverside.com/hosting-analytics/media/289af5b0f81892a858997093a86737b4583b141c7c61eee4f7cbee2e5b96e207/eyJlcGlzb2RlSWQiOiI0ZWIzYWM5Yi0wOTg0LTRkZDItYmZhZS05M2JlYzdhYmE2MDUiLCJwb2RjYXN0SWQiOiJjMGE0YjQ3Yi1iMmM5LTRjNjgtODhiNS0xYmFhM2EzNTJjODMiLCJhY2NvdW50SWQiOiI2OTBiYjRiMzM2NjY3MWFlZGQwZTZhMTEiLCJwYXRoIjoibWVkaWEvY2xpcHMvNjk5OWVjM2Q0ODM2YmQyNDNhN2JjODY3L2Nvcnktc21pdGhzLXN0dWRpby1sTktuWC1jb21wb3Nlci0yMDI2LTItMjFfXzE4LTMyLTQ1Lm1wMyJ9.mp3","audio_url":"https://api.riverside.com/hosting-analytics/media/289af5b0f81892a858997093a86737b4583b141c7c61eee4f7cbee2e5b96e207/eyJlcGlzb2RlSWQiOiI0ZWIzYWM5Yi0wOTg0LTRkZDItYmZhZS05M2JlYzdhYmE2MDUiLCJwb2RjYXN0SWQiOiJjMGE0YjQ3Yi1iMmM5LTRjNjgtODhiNS0xYmFhM2EzNTJjODMiLCJhY2NvdW50SWQiOiI2OTBiYjRiMzM2NjY3MWFlZGQwZTZhMTEiLCJwYXRoIjoibWVkaWEvY2xpcHMvNjk5OWVjM2Q0ODM2YmQyNDNhN2JjODY3L2Nvcnktc21pdGhzLXN0dWRpby1sTktuWC1jb21wb3Nlci0yMDI2LTItMjFfXzE4LTMyLTQ1Lm1wMyJ9.mp3","summary":"In this episode of Galaxy Balance, Cory Smith is joined by Marc Güell, a synthetic biologist working at the frontier of genome engineering, AI-driven biological design, and translational therapeutics. Marc's work spans programmable genome integration systems, synthetic evolution, and the development of biological tools that extend far beyond what natural evolution has produced. From his early training in chemistry and engineering to his time in the Church Lab at Harvard and now leading a research group in Barcelona, Marc's career reflects a consistent focus on building new biological technologies. The conversation explores how generative AI is reshaping genome writing, why engineering principles matter in biology, and what it takes to translate deep-tech synthetic biology into real-world applications. We also discuss the founding of Integra Therapeutics, engineering the skin microbiome as a therapeutic platform, and how imagination influences real life science. 00:00 - How AI enables exploration of unconstrained genotypical spaces in synthetic biology 02:18 - Dr. Guell’s childhood in the Pyrenees fueling his passion for building and discovery 03:14 - From organic chemistry to synthetic genome engineering at Heidelberg and Harvard 05:33 - Recent advances in genome editing: CRISPR, xenotransplantation, and deep tech biotech startups 09:48 - The coming revolution: speaking DNA with AI tools and designing complex genetic circuits 12:30 - Navigating the vast, unconstrained genetic landscape using synthesis-free, AI-guided methods 15:44 - Exploring the complexity of splicing, gene regulation, and the role of AI in modeling biological systems 20:31 - Improving protein design and gene writing with coupled CRISPR and transposases 22:58 - Using AI-generated transposases surpassi…","meta_description":"In this episode of Galaxy Balance, Cory Smith is joined by Marc Güell, a synthetic biologist working at the frontier of genome engineering, AI-driven biol…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3914,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/galaxy-balance-7619530/episodes/marc-g-ell-ai-synthetic-evolution-and-the-future-of-genome-engineering/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/galaxy-balance-7619530/marc-g-ell-ai-synthetic-evolution-and-the-future-of-genome-engineering.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}