{"podcast":{"title":"Galaxy Balance","slug":"galaxy-balance-7619530","podcast_index_feed_id":7619530,"rss_url":"https://api.riverside.fm/hosting/TsNBRv3G.rss","website_url":"https://www.youtube.com/@GalaxyBalance","image_url":"https://hosting-media.riverside.com/media/podcasts/c0a4b47b-b2c9-4c68-88b5-1baa3a352c83/logos/0081482a-5241-4cdc-aa4f-c89d3aca95e7.png","author":"Cory Smith","episode_count":28,"summary":"Galaxy Balance explores the frontier where biology, technology and consciousness meet. Each episode brings together pioneers shaping our collective future, from genome engineers and AI builders to longevity researchers, space explorers, and mindfulness practitioners. Hosted by Cory Smith, the conversations dive deep into how these seemingly distant fields form an interconnected ecosystem, one that balance innovation with introspection, science with spirit, and ambition with awareness. At its core, Galaxy Balance is about integration; the idea that our greatest leaps forward happen when disciplines collide. The same algorithms that decode galaxies can help us understand genomes; the same principles that govern consciousness can illuminate AI. Through long-form, unscripted dialogue, the show invites listeners to zoom out from the silos of specialization and see the larger pattern: a living system of intelligence evolving across scales – molecular, planetary, and cosmic.","last_synced_at":"2026-09-24T00:19:02.360701+00:00","page_url":"https://stenobird.com/podcast/galaxy-balance-7619530"},"episode":{"title":"Li Li: Rewiring Skin Aging With AI and mRNA","slug":"li-li-rewiring-skin-aging-with-ai-and-mrna","published_at":"2026-07-27T21:37:39+00:00","page_url":"https://stenobird.com/podcast/galaxy-balance-7619530/li-li-rewiring-skin-aging-with-ai-and-mrna","show_page_url":"https://stenobird.com/podcast/galaxy-balance-7619530","url":"https://api.riverside.com/hosting-analytics/media/8a4222f882d014e077b062b691cbe04adb6cea6e339a1afca26aca74f8aec0b8/eyJlcGlzb2RlSWQiOiJiYTM3MDhjYS0wMmE0LTQ0YjYtYWU1Ni02ZDY3N2YyNjM0ZDkiLCJwb2RjYXN0SWQiOiJjMGE0YjQ3Yi1iMmM5LTRjNjgtODhiNS0xYmFhM2EzNTJjODMiLCJhY2NvdW50SWQiOiI2OTBiYjRiMzM2NjY3MWFlZGQwZTZhMTEiLCJwYXRoIjoibWVkaWEvY2xpcHMvNmE2MDE2NDI0ZTI4MTQxYzRkYjk5ZDc0L2Nvcnktc21pdGhzLXN0dWRpby1sTktuWC1jb21wb3Nlci0yMDI2LTctMjJfXzMtMC01MC5tcDMifQ==.mp3","audio_url":"https://api.riverside.com/hosting-analytics/media/8a4222f882d014e077b062b691cbe04adb6cea6e339a1afca26aca74f8aec0b8/eyJlcGlzb2RlSWQiOiJiYTM3MDhjYS0wMmE0LTQ0YjYtYWU1Ni02ZDY3N2YyNjM0ZDkiLCJwb2RjYXN0SWQiOiJjMGE0YjQ3Yi1iMmM5LTRjNjgtODhiNS0xYmFhM2EzNTJjODMiLCJhY2NvdW50SWQiOiI2OTBiYjRiMzM2NjY3MWFlZGQwZTZhMTEiLCJwYXRoIjoibWVkaWEvY2xpcHMvNmE2MDE2NDI0ZTI4MTQxYzRkYjk5ZDc0L2Nvcnktc21pdGhzLXN0dWRpby1sTktuWC1jb21wb3Nlci0yMDI2LTctMjJfXzMtMC01MC5tcDMifQ==.mp3","summary":"00:00 - Introduction to Lily and GLife’s vision for data-driven dermatology 01:20 - Lily’s scientific background 02:43 - Breakthroughs from single-cell atlases 03:50 - The motivation behind founding GLife 04:50 - The importance of treating skin as a foundational organ 05:48 - Discovery of key molecular drivers of aging 06:22 - Challenges of fundraising 07:45 - The novel approach to rejuvenating hair loss through targeted messenger RNA treatments 08:53 - How treatments will be delivered via microneedles and micro patches 09:32 - The potential to alter hair color and explore cosmetic applications 10:06 - Balancing platform discovery engines with the development of first-in-class therapeutics 10:43 - The comprehensiveness of the skin atlas and addressing genetic diversity 11:39 - Technical challenges of capturing skin’s cellular heterogeneity and stem cell populations 12:50 - The importance of isoforms and deep sequencing in understanding gene functions 13:16 - Short-lived messenger RNA as a safe, reversible treatment modality 14:55 - Safety considerations and toxicity management 16:01 - Biodistribution studies and local micro-needle delivery safety 17:00 - Next steps towards clinical trials and regenerative therapies for hair loss 18:08 - The role of big data and omics in understanding skin disorders and aging 19:04 - The significance of isoforms in skin biology and gene function 20:13 - Endogenous vs. modified messenger design for safety and efficacy 21:32 - Potential for multi-gene delivery to enhance hair regrowth and color restoration 22:22 - Conception of patches that work with existing hair without shaving 23:38 - Targeting broad hair loss types and the concept of root causes 24:47 - Modeling hair loss with animal models and regulatory considerations 25:48 - Regula…","meta_description":"00:00 - Introduction to Lily and GLife’s vision for data-driven dermatology 01:20 - Lily’s scientific background 02:43 - Breakthroughs from single-cell at…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3454,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/galaxy-balance-7619530/episodes/li-li-rewiring-skin-aging-with-ai-and-mrna/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/galaxy-balance-7619530/li-li-rewiring-skin-aging-with-ai-and-mrna.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}