{"podcast":{"title":"First Principles","slug":"first-principles-7708985","podcast_index_feed_id":7708985,"rss_url":"https://feeds.megaphone.fm/PODAGEN4765221373","website_url":null,"image_url":"https://megaphone.imgix.net/podcasts/06eebd2a-0779-11f1-826e-37926ac18342/image/fca7c8febd1441fc3b0d54084418b06d.png?ixlib=rails-4.3.1&max-w=3000&max-h=3000&fit=crop&auto=format,compress","author":"Adrian Wells","episode_count":426,"summary":"First Principles isn't another business podcast recycling the same startup stories. Adrian Wells takes the fundamentals that actually matter and breaks them down like you're having coffee with the smartest professor you ever had. Wells spent twelve years teaching philosophy and critical thinking before ditching the lecture hall for the microphone. Turns out, the same principles that help you think clearly about ancient Greek ethics also work pretty well for modern business decisions. Who knew? Every episode strips away the latest trends and buzzwords to focus on the core ideas that don't change. How to actually evaluate evidence when everyone's throwing around statistics. Why most \"revolutionary\" business advice is just old wine in new bottles. The thinking patterns that separate smart decisions from lucky guesses. You won't get hyped-up success stories or flavor-of-the-month strategies. Instead, you'll learn how to think through problems the way philosophers have for centuries, applied to the stuff that matters in your work and life right now. Multiple new episodes drop daily, so there's always something fresh when you need it. Follow now if you're ready to think better, not just…","last_synced_at":"2026-09-20T02:18:54.580675+00:00","page_url":"https://stenobird.com/podcast/first-principles-7708985"},"episode":{"title":"Wim Hof: The $47M Disease Industry Doesn't Want You Knowing This","slug":"wim-hof-the-47m-disease-industry-doesn-t-want-you-knowing-this","published_at":"2026-09-10T03:33:00+00:00","page_url":"https://stenobird.com/podcast/first-principles-7708985/wim-hof-the-47m-disease-industry-doesn-t-want-you-knowing-this","show_page_url":"https://stenobird.com/podcast/first-principles-7708985","url":"https://traffic.megaphone.fm/PODAGEN8647537300.mp3?updated=1776258387","audio_url":"https://traffic.megaphone.fm/PODAGEN8647537300.mp3?updated=1776258387","summary":"What if everything you've been told about fighting disease and inflammation is keeping you sick? Adrian Wells breaks down how Wim Hof's controversial methods might actually work through measurable biological mechanisms that the medical establishment is just starting to understand. 🎯 What You'll Learn: • How Hof's trained participants showed 50% less inflammatory response when injected with bacterial endotoxin in a controlled study • Why brain imaging reveals his breathing method activates the periaqueductal gray area that controls pain and stress responses • The science behind 530% increases in noradrenaline levels and how cold exposure can boost metabolism by 15% 👤 Perfect for: lifelong learners and anyone passionate about personal growth who wants to understand what science actually says about immune function and inflammation control. 📍 Chapters: [00:00] Adrian Wells introduces the $47M question about disease treatment [01:30] The 2014 endotoxin study that shocked researchers [04:00] Brain imaging reveals how breathing changes neural pathways [07:00] Noradrenaline spikes and what they mean for your immune system [10:00] Cold exposure science: brown fat activation and metabolic benefits [12:00] Practical takeaways you can test yourself The implications are pretty wild. If controlled breathing and cold exposure can measurably influence immune response, why isn't this being studied more aggressively? Wells walks through the actual research without the hype, showing you what the data really says about inflammation, stress response, and immune function. 🔔 Never miss an episode: Follow First Principles on Spotify or Apple Podcasts and turn on notifications. New episodes drop daily, your next favorite insight is one tap away. 🔍 Topics: Wim Hof method, inflammation research,…","meta_description":"What if everything you've been told about fighting disease and inflammation is keeping you sick? Adrian Wells breaks down how Wim Hof's controversial meth…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1608,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/first-principles-7708985/episodes/wim-hof-the-47m-disease-industry-doesn-t-want-you-knowing-this/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/first-principles-7708985/wim-hof-the-47m-disease-industry-doesn-t-want-you-knowing-this.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}