{"podcast":{"title":"First Principles","slug":"first-principles-7708985","podcast_index_feed_id":7708985,"rss_url":"https://feeds.megaphone.fm/PODAGEN4765221373","website_url":null,"image_url":"https://megaphone.imgix.net/podcasts/06eebd2a-0779-11f1-826e-37926ac18342/image/fca7c8febd1441fc3b0d54084418b06d.png?ixlib=rails-4.3.1&max-w=3000&max-h=3000&fit=crop&auto=format,compress","author":"Adrian Wells","episode_count":324,"summary":"First Principles isn't another business podcast recycling the same startup stories. Adrian Wells takes the fundamentals that actually matter and breaks them down like you're having coffee with the smartest professor you ever had. Wells spent twelve years teaching philosophy and critical thinking before ditching the lecture hall for the microphone. Turns out, the same principles that help you think clearly about ancient Greek ethics also work pretty well for modern business decisions. Who knew? Every episode strips away the latest trends and buzzwords to focus on the core ideas that don't change. How to actually evaluate evidence when everyone's throwing around statistics. Why most \"revolutionary\" business advice is just old wine in new bottles. The thinking patterns that separate smart decisions from lucky guesses. You won't get hyped-up success stories or flavor-of-the-month strategies. Instead, you'll learn how to think through problems the way philosophers have for centuries, applied to the stuff that matters in your work and life right now. Multiple new episodes drop daily, so there's always something fresh when you need it. Follow now if you're ready to think better, not just…","last_synced_at":"2026-07-23T16:19:48.696188+00:00","page_url":"https://stenobird.com/podcast/first-principles-7708985"},"episode":{"title":"This 46-Year-Old Tech CEO Spends $2M a Year to Age Backwards (It's Working)","slug":"this-46-year-old-tech-ceo-spends-2m-a-year-to-age-backwards-it-s-working","published_at":"2026-07-17T22:57:00+00:00","page_url":"https://stenobird.com/podcast/first-principles-7708985/this-46-year-old-tech-ceo-spends-2m-a-year-to-age-backwards-it-s-working","show_page_url":"https://stenobird.com/podcast/first-principles-7708985","url":"https://traffic.megaphone.fm/PODAGEN2854733358.mp3?updated=1776257624","audio_url":"https://traffic.megaphone.fm/PODAGEN2854733358.mp3?updated=1776257624","summary":"What if a tech CEO could actually reverse aging? Bryan Johnson was biologically 45. Now tests show he's 18. And he's documenting everything. In this episode, Adrian Wells breaks down the most extreme anti-aging experiment ever attempted. Johnson spends $2 million yearly on a protocol that's producing measurable results. We're talking blood transfusions from his teenage son, 100+ daily supplements, and medical procedures that sound like science fiction. 🎯 What You'll Learn: • Why Johnson's $2M protocol includes eating exactly 1,977 calories daily (and the science behind precision nutrition) • The controversial plasma exchange treatments that filter and replace his blood monthly • How epigenetic testing measures biological age vs chronological age (and what Johnson's results actually mean) • The full-time medical team monitoring his every biomarker 24/7 👤 Perfect for: lifelong learners and anyone curious about the cutting edge of human optimization and longevity science. 📍 Chapters: [00:00] Adrian Wells introduces the man aging backwards [01:45] The $2 million annual protocol breakdown [03:30] Blood transfusions from his teenage son [05:15] 100+ supplements and exact calorie counting [07:00] Epigenetic age testing: 45 to 18 years old [09:30] The medical team and daily monitoring [11:00] What this means for the future of aging This isn't about expensive supplements you can't afford. It's about understanding what's possible when someone goes all-in on longevity science. Johnson's treating his body like a controlled experiment, and the data is fascinating. 🔔 Never miss an episode: Follow First Principles on Spotify or Apple Podcasts and turn on notifications. New episodes drop daily, your next favorite insight is one tap away. 🔍 Topics: anti-aging, longevity science, Bryan…","meta_description":"What if a tech CEO could actually reverse aging? Bryan Johnson was biologically 45. Now tests show he's 18. And he's documenting everything. In this episo…","key_points":[],"chapters":[],"topics":[],"duration_seconds":826,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/first-principles-7708985/episodes/this-46-year-old-tech-ceo-spends-2m-a-year-to-age-backwards-it-s-working/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/first-principles-7708985/this-46-year-old-tech-ceo-spends-2m-a-year-to-age-backwards-it-s-working.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}