{"podcast":{"title":"First Principles","slug":"first-principles-7708985","podcast_index_feed_id":7708985,"rss_url":"https://feeds.megaphone.fm/PODAGEN4765221373","website_url":null,"image_url":"https://megaphone.imgix.net/podcasts/06eebd2a-0779-11f1-826e-37926ac18342/image/fca7c8febd1441fc3b0d54084418b06d.png?ixlib=rails-4.3.1&max-w=3000&max-h=3000&fit=crop&auto=format,compress","author":"Adrian Wells","episode_count":324,"summary":"First Principles isn't another business podcast recycling the same startup stories. Adrian Wells takes the fundamentals that actually matter and breaks them down like you're having coffee with the smartest professor you ever had. Wells spent twelve years teaching philosophy and critical thinking before ditching the lecture hall for the microphone. Turns out, the same principles that help you think clearly about ancient Greek ethics also work pretty well for modern business decisions. Who knew? Every episode strips away the latest trends and buzzwords to focus on the core ideas that don't change. How to actually evaluate evidence when everyone's throwing around statistics. Why most \"revolutionary\" business advice is just old wine in new bottles. The thinking patterns that separate smart decisions from lucky guesses. You won't get hyped-up success stories or flavor-of-the-month strategies. Instead, you'll learn how to think through problems the way philosophers have for centuries, applied to the stuff that matters in your work and life right now. Multiple new episodes drop daily, so there's always something fresh when you need it. Follow now if you're ready to think better, not just…","last_synced_at":"2026-07-23T16:19:48.696188+00:00","page_url":"https://stenobird.com/podcast/first-principles-7708985"},"episode":{"title":"Dr Sampson: The Mouth Bacteria That's Secretly Destroying Your Brain","slug":"dr-sampson-the-mouth-bacteria-that-s-secretly-destroying-your-brain","published_at":"2026-07-20T05:51:00+00:00","page_url":"https://stenobird.com/podcast/first-principles-7708985/dr-sampson-the-mouth-bacteria-that-s-secretly-destroying-your-brain","show_page_url":"https://stenobird.com/podcast/first-principles-7708985","url":"https://traffic.megaphone.fm/PODAGEN9943308313.mp3?updated=1776257684","audio_url":"https://traffic.megaphone.fm/PODAGEN9943308313.mp3?updated=1776257684","summary":"What if the bacteria in your mouth right now is quietly rewiring your brain for Alzheimer's disease? Adrian Wells breaks down the shocking research connecting your oral health to cognitive decline in ways that will make you rethink your dental routine forever. This isn't about cavities or bad breath. We're talking about bacterial invaders that can reach your brain in 24 hours and start dismantling the proteins that form your memories. 🎯 What You'll Learn: • Why 96% of Alzheimer's patients have the same mouth bacteria in their brain tissue • How people with severe gum disease show 70% higher rates of cognitive decline over 20 years • The exact pathway bacteria use to travel from inflamed gums to brain cells • Simple daily habits that can protect both your teeth and your memory 👤 Perfect for: lifelong learners and anyone passionate about personal growth who wants to understand the hidden connections between different body systems. 📍 Chapters: [00:00] Adrian introduces the mouth-brain connection bombshell [01:45] The Porphyromonas gingivalis discovery that changed everything [03:30] How bacteria hijack your bloodstream in under 24 hours [05:15] The protein destruction happening in Alzheimer's brains [07:45] Why your dentist might be your best defense against dementia [09:30] Daily habits that protect your oral microbiome [11:15] Key takeaways you can use starting tonight This episode will change how you think about brushing your teeth. It's not just about oral health anymore, it's about protecting your brain for decades to come. 🔔 Never miss an episode: Follow First Principles on Spotify or Apple Podcasts and turn on notifications. New episodes drop daily, your next favorite insight is one tap away. 🔍 Topics: oral microbiome, Alzheimer's prevention, brain health, gum dise…","meta_description":"What if the bacteria in your mouth right now is quietly rewiring your brain for Alzheimer's disease? Adrian Wells breaks down the shocking research connec…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1030,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/first-principles-7708985/episodes/dr-sampson-the-mouth-bacteria-that-s-secretly-destroying-your-brain/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/first-principles-7708985/dr-sampson-the-mouth-bacteria-that-s-secretly-destroying-your-brain.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}