{"podcast":{"title":"Extend Podcast with Darshan Shah, MD","slug":"extend-podcast-with-darshan-shah-md-7064213","podcast_index_feed_id":7064213,"rss_url":"https://feeds.libsyn.com/551312/rss","website_url":"https://drshah.com/","image_url":"https://static.libsyn.com/p/assets/d/5/1/7/d5176cf64b959ae8e55e3c100dce7605/DARSHAN_SHAH_MD.-3.png","author":"Darshan Shah, MD","episode_count":172,"summary":"Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health. Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.","last_synced_at":"2026-06-09T18:18:24.162936+00:00","page_url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213"},"episode":{"title":"166. Carolina Reis de Oliveira: The Missing Link Between Skin and Longevity","slug":"166-carolina-reis-de-oliveira-the-missing-link-between-skin-and-longevity","published_at":"2026-05-21T08:17:00+00:00","page_url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213/166-carolina-reis-de-oliveira-the-missing-link-between-skin-and-longevity","show_page_url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213","url":"https://03add746-5496-41d9-bcc9-511a526491e9.libsyn.com/166-carolina-reis-de-oliveira-the-missing-link-between-skin-and-longevity","audio_url":"https://traffic.libsyn.com/secure/03add746-5496-41d9-bcc9-511a526491e9/Extend_-_Caroline_Reis.mp3?dest-id=4758622","summary":"If you think your skincare routine is protecting your skin, this conversation may make you look at your bathroom shelf differently. You've been taught to treat your skin like something cosmetic, something you maintain for how it looks. But your skin is your largest organ, it has its own biological age, and if you are not supporting it properly, it can become a constant source of inflammation and damage that goes far beyond appearance. We dive deeper into this in Extend with Carolina Reis de Oliveira, PhD. We also break down why most skincare products are not built to target the biology of aging, how senescent cells drive visible and invisible skin aging, and how OS-01, discovered through machine learning, is designed to slow the spread of these dysfunctional cells so you can actually support your skin as part of your longevity strategy. Carolina Reis de Oliveira, PhD, is a stem cell biologist, tissue engineer, and co-founder and CEO of OneSkin. She has spent over a decade researching cellular aging, building human skin models in the lab, and developing epigenetic clocks to measure biological skin age, with her work on OS-01 validated through peer-reviewed research, making her one of the leading voices translating longevity science into real-world applications for skin. For a limited time, you can try OneSkin for 15% off with code EXTEND at oneskin.co/EXTEND That's 15% off oneskin.co with code EXTEND What's Discussed: (2:02) Why OneSkin started by asking what actually targets skin aging at the cellular level. (4:02) How popular anti-aging products can cause inflammation and damage. (9:25) The three main drivers of skin aging: senescence, inflammation, and collagen breakdown. (11:24) Why UV exposure is responsible for most visible skin aging. (21:33) How OS-01 was discov…","meta_description":"If you think your skincare routine is protecting your skin, this conversation may make you look at your bathroom shelf differently. You've been taught to…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3426,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/extend-podcast-with-darshan-shah-md-7064213/episodes/166-carolina-reis-de-oliveira-the-missing-link-between-skin-and-longevity/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213/166-carolina-reis-de-oliveira-the-missing-link-between-skin-and-longevity.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}