{"podcast":{"title":"Extend Podcast with Darshan Shah, MD","slug":"extend-podcast-with-darshan-shah-md-7064213","podcast_index_feed_id":7064213,"rss_url":"https://feeds.libsyn.com/551312/rss","website_url":"https://drshah.com/","image_url":"https://static.libsyn.com/p/assets/d/5/1/7/d5176cf64b959ae8e55e3c100dce7605/DARSHAN_SHAH_MD.-3.png","author":"Darshan Shah, MD","episode_count":172,"summary":"Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health. Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.","last_synced_at":"2026-06-09T18:18:24.162936+00:00","page_url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213"},"episode":{"title":"160. Dr. Kara Fitzgerald on Biological Age, Epigenetic Clocks, and the Future of Aging Reversal","slug":"160-dr-kara-fitzgerald-on-biological-age-epigenetic-clocks-and-the-future-of-aging-reversal","published_at":"2026-04-30T09:00:00+00:00","page_url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213/160-dr-kara-fitzgerald-on-biological-age-epigenetic-clocks-and-the-future-of-aging-reversal","show_page_url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213","url":"https://03add746-5496-41d9-bcc9-511a526491e9.libsyn.com/160-dr-kara-fitzgerald-on-biological-age-epigenetic-clocks-and-the-future-of-aging-reversal","audio_url":"https://traffic.libsyn.com/secure/03add746-5496-41d9-bcc9-511a526491e9/Extend_-_Dr._Kara_Fitzgerald_2.mp3?dest-id=4758622","summary":"Biological aging is no longer just a concept tied to time. It is something we can now measure, track, and influence through data, lifestyle, and targeted interventions that directly impact how our cells function and age. In this episode of Extend, we sit down with Dr. Kara Fitzgerald, functional medicine leader, researcher, and author, to unpack how diet and lifestyle can directly influence epigenetics and biological age. We break down the difference between chronological and biological aging, how epigenetic clocks work across organs and systems, and why aging may be driven by both environmental exposures and deeper programmed mechanisms. We also explore how polyphenols, nutrient-dense diets, and emerging interventions like Yamanaka mimetics may begin to shift the trajectory of aging at the cellular level and open new pathways for extending healthspan and peak performance. Dr. Kara Fitzgerald is a functional medicine physician, researcher, and author of Younger You, known for her pioneering clinical studies demonstrating how targeted nutrition and lifestyle interventions can reverse biological age and reshape long-term health outcomes. What We Discuss: (01:36) Aging, performance, and menopause (05:01) Healthspan vs peak span (08:39) The dark matter of nutrition (11:36) Polyphenols and urolithin A (13:12) Biological age and epigenetics (15:41) Epigenetic clocks and measurement (21:02) Exposomic aging (25:03) Programmed aging (28:20) Yamanaka factors (33:24) Yamanaka mimetics (36:29) Polyphenols and caloric restriction (40:33) Nutrition and biological age reversal Thank You to Our Sponsors: IM8: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH . Momentous: Head to livemomentou…","meta_description":"Biological aging is no longer just a concept tied to time. It is something we can now measure, track, and influence through data, lifestyle, and targeted…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2843,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/extend-podcast-with-darshan-shah-md-7064213/episodes/160-dr-kara-fitzgerald-on-biological-age-epigenetic-clocks-and-the-future-of-aging-reversal/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213/160-dr-kara-fitzgerald-on-biological-age-epigenetic-clocks-and-the-future-of-aging-reversal.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}