{"podcast":{"title":"Extend Podcast with Darshan Shah, MD","slug":"extend-podcast-with-darshan-shah-md-7064213","podcast_index_feed_id":7064213,"rss_url":"https://feeds.libsyn.com/551312/rss","website_url":"https://drshah.com/","image_url":"https://static.libsyn.com/p/assets/d/5/1/7/d5176cf64b959ae8e55e3c100dce7605/DARSHAN_SHAH_MD.-3.png","author":"Darshan Shah, MD","episode_count":172,"summary":"Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health. Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.","last_synced_at":"2026-06-09T18:18:24.162936+00:00","page_url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213"},"episode":{"title":"159: Dr. Anurag Singh: Urolithin A, Mitophagy, and Mitochondrial Health","slug":"159-dr-anurag-singh-urolithin-a-mitophagy-and-mitochondrial-health","published_at":"2026-04-28T08:00:00+00:00","page_url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213/159-dr-anurag-singh-urolithin-a-mitophagy-and-mitochondrial-health","show_page_url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213","url":"https://03add746-5496-41d9-bcc9-511a526491e9.libsyn.com/159-dr-anurag-singh-urolithin-a-mitophagy-and-mitochondrial-health","audio_url":"https://traffic.libsyn.com/secure/03add746-5496-41d9-bcc9-511a526491e9/Extend_-_Dr._Singh.mp3?dest-id=4758622","summary":"Mitochondrial decline is one of the most overlooked drivers of aging, impacting energy, muscle function, cognitive performance, and immune resilience long before symptoms become obvious. Many of the changes we associate with aging may actually stem from a loss of cellular efficiency and the body's ability to renew itself. In this episode of Extend, I sit down with Dr. Anurag Singh, Chief Medical Officer at Timeline, to unpack the science behind urolithin A and how mitochondrial health shapes longevity. We break down how the gut microbiome influences cellular function, why mitophagy declines with age, and what clinical research shows about improving muscle strength, recovery, metabolic health, and immune function. We also explore how targeted supplementation and lifestyle strategies can help restore mitochondrial quality and support long-term performance and resilience. Dr. Anurag Singh is a physician-scientist with an M.D. in internal medicine and a Ph.D. in immunology, currently serving as Chief Medical Officer at Timeline, where he leads the development of advanced nutritional and skincare products focused on mitochondrial and cellular health. What We Discuss: (04:58) Drug vs nutraceutical and what urolithin A actually is (06:23) Gut microbiome differences and why most people don't produce it (08:11) How urolithin A is made from diet and polyphenols (10:25) Effective dosing and supplementation strategy (15:32) What mitochondria are and why they matter for aging (21:26) Mitophagy and how mitochondrial quality declines over time (23:43) Main drivers of mitochondrial damage (26:24) How urolithin A supports cellular renewal (28:55) Muscle aging, strength, and performance (33:07) Clinical trial results in older and sedentary adults (35:32) Effects on recovery in elite ath…","meta_description":"Mitochondrial decline is one of the most overlooked drivers of aging, impacting energy, muscle function, cognitive performance, and immune resilience long…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3511,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/extend-podcast-with-darshan-shah-md-7064213/episodes/159-dr-anurag-singh-urolithin-a-mitophagy-and-mitochondrial-health/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213/159-dr-anurag-singh-urolithin-a-mitophagy-and-mitochondrial-health.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}