{"podcast":{"title":"Epigenetics Podcast","slug":"epigenetics-podcast-809637","podcast_index_feed_id":809637,"rss_url":"https://activemotif.podbean.com/feed.xml","website_url":"https://activemotif.podbean.com","image_url":"https://pbcdn1.podbean.com/imglogo/image-logo/1812346/AM_podcast_logo.png","author":"Active Motif","episode_count":178,"summary":"Discover the stories behind the science!","last_synced_at":"2026-07-02T16:19:12.078239+00:00","page_url":"https://stenobird.com/podcast/epigenetics-podcast-809637"},"episode":{"title":"Decoding Cell Fate Through 3D Genome Organization and Chromatin Dynamics (Srinjan Basu)","slug":"decoding-cell-fate-through-3d-genome-organization-and-chromatin-dynamics-srinjan-basu","published_at":"2026-02-12T08:01:00+00:00","page_url":"https://stenobird.com/podcast/epigenetics-podcast-809637/decoding-cell-fate-through-3d-genome-organization-and-chromatin-dynamics-srinjan-basu","show_page_url":"https://stenobird.com/podcast/epigenetics-podcast-809637","url":"https://activemotif.podbean.com/e/decoding-cell-fate-through-3d-genome-organization-and-chromatin-dynamics-srinjan-basu/","audio_url":"https://mcdn.podbean.com/mf/web/54942zqb56dr7598/AMP168_-_Srinjan_Basu67rha.mp3","summary":"In this episode of the Epigenetics Podcast, we talked with Srinjan Basu from Imperial College London to talk about his work on how chromatin architecture and epigenetic mechanisms orchestrate developmental gene expression programs. We begin by exploring Dr. Basu's early work at Harvard which involved pioneering Raman-based label-free imaging, allowing the study of chromatin dynamics in live tissue. Here, he tackles technical challenges faced in visualizing DNA interactions, emphasizing the shift from 2D to 3D analysis and the importance of real-time observation of chromatin behavior under various conditions. This segues into his groundbreaking research on single transcription factors interacting with chromatin, revealing subtle but significant changes in the dynamics of gene regulation. We transition into the complexities of chromatin architecture as Dr. Basu recounts his efforts in mapping the entire mouse genome in single pluripotent cells, unearthing unexpected heterogeneity among cells. This heterogeneity raises intriguing questions about its impact on cellular function, prompting ongoing investigations into chromatin dynamics and the role of remodeling complexes like NuRD in cell fate transitions. Dr. Basu elucidates how recent studies have begun to bridge the gaps in understanding how transcription factors and chromatin dynamics interact during cellular decisions, particularly emphasizing the influence of mechanical signals and the intrinsic properties of cells. His research underscores the idea that stem cells undergo a preparatory phase for differentiation, highlighting the critical balance of intrinsic and extrinsic factors that govern genetic expression and cellular outcomes. We also talk about Dr. Basu's current research trajectory, focusing on enhancing ima…","meta_description":"In this episode of the Epigenetics Podcast, we talked with Srinjan Basu from Imperial College London to talk about his work on how chromatin architecture…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2480,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/epigenetics-podcast-809637/episodes/decoding-cell-fate-through-3d-genome-organization-and-chromatin-dynamics-srinjan-basu/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/epigenetics-podcast-809637/decoding-cell-fate-through-3d-genome-organization-and-chromatin-dynamics-srinjan-basu.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}