{"podcast":{"title":"Dwarkesh Podcast","slug":"dwarkesh-podcast","podcast_index_feed_id":1251189,"rss_url":"https://api.substack.com/feed/podcast/69345.rss","website_url":"https://www.dwarkesh.com/podcast","image_url":"https://substackcdn.com/feed/podcast/69345/db6ef1755a45c6e0e7a478f6dbe68984.jpg","author":"Dwarkesh Patel","episode_count":128,"summary":"Deeply researched interviews","last_synced_at":"2026-06-05T06:19:20.066984+00:00","page_url":"https://stenobird.com/podcast/dwarkesh-podcast"},"episode":{"title":"Evolution designed us to die fast; we can change that — Jacob Kimmel","slug":"evolution-designed-us-to-die-fast-we-can-change-that-jacob-kimmel","published_at":"2025-08-21T16:29:18+00:00","page_url":"https://stenobird.com/podcast/dwarkesh-podcast/evolution-designed-us-to-die-fast-we-can-change-that-jacob-kimmel","show_page_url":"https://stenobird.com/podcast/dwarkesh-podcast","url":"https://www.dwarkesh.com/p/jacob-kimmel","audio_url":"https://api.substack.com/feed/podcast/171561010/726c799e23e6cf9e4dbd687a63df92f0.mp3","summary":"Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene delivery and Jacob’s controversial takes on CAR-T cells. For full disclosure, I am an angel investor in NewLimit. This did not impact my decision to interview Jacob, nor the questions I asked him. Watch on YouTube ; listen on Apple Podcasts or Spotify. SPONSORS * Hudson River Trading uses deep learning to tackle one of the world's most complex systems: global capital allocation. They have a massive in-house GPU cluster, and they’re constantly adding new racks of B200s to ensure their researchers are never constrained by compute. Explore opportunities at hudsonrivertrading.com/dwarkesh \\ * Google’s Gemini CLI turns ideas into working applications FAST, no coding required. It built a complete podcast post-production tool in 10 minutes, including fully functional backend logic, and the entire build used less than 10% of Gemini’s session context. Check it out on Github now! * To sponsor a future episode, visit dwarkesh.com/advertise . TIMESTAMPS (00:00:00) – Three reasons evolution didn’t optimize for longevity (00:12:07) – Why didn't humans evolve their own antibiotics? (00:25:26) – De-aging cells via epigenetic reprogramming (00:44:43) – Viral vectors and other delivery mechanisms (01:06:22) – Synthetic transcription factors (01:09:31) – Can virtual cells break Eroom’s Law? (01:31:32) – Economic models for pharma Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe","meta_description":"Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t opti…","key_points":[],"chapters":[],"topics":[],"duration_seconds":6280,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/dwarkesh-podcast/episodes/evolution-designed-us-to-die-fast-we-can-change-that-jacob-kimmel/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/dwarkesh-podcast/evolution-designed-us-to-die-fast-we-can-change-that-jacob-kimmel.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}