{"podcast":{"title":"Dr. John Campbell","slug":"dr-john-campbell-7851784","podcast_index_feed_id":7851784,"rss_url":"https://feeds.megaphone.fm/VG9554039150","website_url":null,"image_url":"https://megaphone.imgix.net/podcasts/7a133470-32e4-11f1-ae26-ef5a830a5f06/image/aacd596ff9b51467520b0238cfcd1c87.png?ixlib=rails-4.3.1&max-w=3000&max-h=3000&fit=crop&auto=format,compress","author":"Campbellteaching","episode_count":480,"summary":"Hello Everyone, My name is John Campbell and I am a retired Nurse Teacher and former clinical nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally. LinkedIn profile, https://www.linkedin.com/in/dr-john-campbell-5256223b/ Twitter, https://twitter.com/Johnincarlisle Disclaimer; These media including videos, book, e book, articles, podcasts are not peer-reviewed. They should never replace individual clinical judgement from your own health care provider. No media-based material on this channel is suitable for using as professional medical advice. All comments are also for educational purposed only and must never replace advice from your own health care provider","last_synced_at":"2026-07-23T10:19:57.883522+00:00","page_url":"https://stenobird.com/podcast/dr-john-campbell-7851784"},"episode":{"title":"Inadvertant intravenous injections","slug":"inadvertant-intravenous-injections","published_at":"2026-07-11T06:15:00+00:00","page_url":"https://stenobird.com/podcast/dr-john-campbell-7851784/inadvertant-intravenous-injections","show_page_url":"https://stenobird.com/podcast/dr-john-campbell-7851784","url":"https://traffic.megaphone.fm/VG8837670333.mp3","audio_url":"https://traffic.megaphone.fm/VG8837670333.mp3","summary":"Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab707/6353927 Background Post-vaccination myocarditis and pericarditis reported after coronavirus mRNA vaccines. The effect of accidental intravenous injection of this vaccine on the heart is unknown Methods in mice Compared difference between i.m. and i.v. injection of vaccine Clinical manifestations Histopathological changes Tissue mRNA expression Serum levels of cytokines and troponins With normal saline (NS) control Results Intravenous SARS-CoV-2 mRNA Vaccine Administration Induced Grossly Visible Pathology in Heart Only IV group developed histopathological changes of myopericarditis Evidenced by cardiomyocyte degeneration Apoptosis Necrosis with adjacent inflammatory cell infiltration Calcific deposits on visceral pericardium But Evidence of coronary artery or other cardiac pathologies was absent Spike antigen (immunostaining) occasionally found in infiltrating immune cells of the heart And in cardiomyocytes and intracardiac vascular endothelial cells The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks and were markedly aggravated by a second IM- or IV-booster dose Numerous inflammatory cytokines found in cardiac tissue (interleukin (IL)-1β, interferon (IFN)-β, IL-6, and tumor necrosis factor (TNF)-α) in the IV group but not the IM group compatible with presence of myopericarditis in the IV group Ballooning degeneration of hepatocytes was consistently found in the IV group. All other organs appeared normal. Conclusions In vivo evidence that inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis. Brief with…","meta_description":"Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model https://academic.oup.com/cid/adv…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1668,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/dr-john-campbell-7851784/episodes/inadvertant-intravenous-injections/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/dr-john-campbell-7851784/inadvertant-intravenous-injections.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}