{"podcast":{"title":"Dr. John Campbell","slug":"dr-john-campbell-7851784","podcast_index_feed_id":7851784,"rss_url":"https://feeds.megaphone.fm/VG9554039150","website_url":null,"image_url":"https://megaphone.imgix.net/podcasts/7a133470-32e4-11f1-ae26-ef5a830a5f06/image/aacd596ff9b51467520b0238cfcd1c87.png?ixlib=rails-4.3.1&max-w=3000&max-h=3000&fit=crop&auto=format,compress","author":"Campbellteaching","episode_count":658,"summary":"Hello Everyone, My name is John Campbell and I am a retired Nurse Teacher and former clinical nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally. LinkedIn profile, https://www.linkedin.com/in/dr-john-campbell-5256223b/ Twitter, https://twitter.com/Johnincarlisle Disclaimer; These media including videos, book, e book, articles, podcasts are not peer-reviewed. They should never replace individual clinical judgement from your own health care provider. No media-based material on this channel is suitable for using as professional medical advice. All comments are also for educational purposed only and must never replace advice from your own health care provider","last_synced_at":"2026-09-22T06:22:02.195523+00:00","page_url":"https://stenobird.com/podcast/dr-john-campbell-7851784"},"episode":{"title":"Depression, I was wrong","slug":"depression-i-was-wrong","published_at":"2026-09-14T05:05:00+00:00","page_url":"https://stenobird.com/podcast/dr-john-campbell-7851784/depression-i-was-wrong","show_page_url":"https://stenobird.com/podcast/dr-john-campbell-7851784","url":"https://traffic.megaphone.fm/VG3153523228.mp3","audio_url":"https://traffic.megaphone.fm/VG3153523228.mp3","summary":"Depression and serotonin (UK, July 2022) https://www.nature.com/articles/s41380-022-01661-0?utm_medium=affiliate&utm_source=commission_junction&utm_campaign=CONR_PF018_ECOM_GL_PHSS_ALWYS_DEEPLINK&utm_content=textlink&utm_term=PID100094349&CJEVENT=963aad7f0ccb11ed8065b3550a180512 Moncrieff, J., Cooper, R.E., Stockmann, T. et al. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry (2022). https://doi.org/10.1038/s41380-022-01661-0 The serotonin theory of depression: a systematic umbrella review of the evidence We aimed to synthesise and evaluate evidence, whether depression is associated with lowered serotonin Studies included 17 studies, 12 systematic reviews and meta-analyses, 5 other relevant studies Serotonin metabolite, 5-HIAA levels unchanged https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773935/ Serotonin (neurotransmitter), quickly metabolized Serotonin ----- MAO ------ 5-hydroxy indole acetic acid (5HIAA) (5-hydroxyindoleacetic acid) Plasma 5-HIAA, showed no association with depression Cerebrospinal fluid 5-HIAA, showed no association with depression Plasma serotonin Showed no relationship with depression Several studies of post-menopausal women, revealed lower levels of plasma 5-HT in women with depression, (p more than 0.05) Serotonin receptors 5-HT1A post synaptic receptor In depression (caused by reduced serotonin) expected to show increased activity of 5-HT1A receptors Studies found either no difference in 5-HT1A receptors (between people with depression and controls), or a lower level of these receptors Tryptophan depletion Studies found no effect in healthy volunteers, but weak evidence of an effect in those with a family history of depression Studies of the Serotonin transporter (SERT) gene…","meta_description":"Depression and serotonin (UK, July 2022) https://www.nature.com/articles/s41380-022-01661-0?utm_medium=affiliate&utm_source=commission_junction&ut…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1237,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/dr-john-campbell-7851784/episodes/depression-i-was-wrong/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/dr-john-campbell-7851784/depression-i-was-wrong.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}