{"podcast":{"title":"Dr. Chapa's OBGYN No Spin Podcast","slug":"dr-chapa-s-obgyn-no-spin-podcast-7407953","podcast_index_feed_id":7407953,"rss_url":"https://media.rss.com/dr-chapa-s-obgyn-no-spin-podcast/feed.xml","website_url":"https://drchapasobgynnospin.codeadx.me/","image_url":"https://media.rss.com/dr-chapa-s-obgyn-no-spin-podcast/podcast_cover_20260610_040615_e5100c670a01e631427748b502e678b0.png","author":"Hector Chapa","episode_count":148,"summary":"Relevant, evidence based, and practical information for medical students, residents, and practicing healthcare providers regarding all things women’s healthcare! This podcast is intended to be clinically relevant, engaging, and FUN, because medical education should NOT be boring! PLUS...we believe that medical education should be delivered without any SPIN...Welcome, to Dr. Chapa's OBGYN No Spin Podcast! (Note: our Legacy podcast, Clinical Pearls, will no longer have new episodes uploaded through that channel, as we have now rebranded with this new adventure.)","last_synced_at":"2026-06-16T00:19:48.478943+00:00","page_url":"https://stenobird.com/podcast/dr-chapa-s-obgyn-no-spin-podcast-7407953"},"episode":{"title":"VOMIT Trial: Mirtazapine vs Ondansetron for HG","slug":"vomit-trial-mirtazapine-vs-ondansetron-for-hg","published_at":"2026-05-18T15:07:18+00:00","page_url":"https://stenobird.com/podcast/dr-chapa-s-obgyn-no-spin-podcast-7407953/vomit-trial-mirtazapine-vs-ondansetron-for-hg","show_page_url":"https://stenobird.com/podcast/dr-chapa-s-obgyn-no-spin-podcast-7407953","url":"https://rss.com/podcasts/dr-chapa-s-obgyn-no-spin-podcast/2835973","audio_url":"https://content.rss.com/episodes/337911/2835973/dr-chapa-s-obgyn-no-spin-podcast/2026_05_18_15_04_53_3a7e570d-947f-4ff8-b770-87eb0d658ad6.mp3","summary":"Hyperemesis gravidarum (HG) represents the most severe end of the nausea and vomiting of pregnancy spectrum. It has a reported incidence of approximately 0.3–3% of pregnancies and is the most common cause of hospitalization in early pregnancy and the second most common cause of hospitalization in pregnancy overall. In June 2024, the ACOG published a Clinical Expert series summarizing the inpatient management of HG. In that guidance, it describes mirtazapine as an “alternative pharmacologic” option. How effective is this medication compared to ondansetron? A new study (published ahead of print on 12/30/25 and officially out June 2026), out of Denmark, sheds some new light on this medication. This trial is the first double-blind RCT comparing mirtazapine to ondansetron AND placebo. Although a BIG limitation of this study exists (which we will discuss), it does provide some interesting insights. Listen in for details. 1. (ACOG CES) Clark, Shannon M. MD; Zhang, Xue MD; Goncharov, Daphne Arena MD. Inpatient Management of Hyperemesis Gravidarum. Obstetrics & Gynecology 143(6):p 745-758, June 2024. | DOI: 10.1097/AOG.0000000000005518 2. Ostenfeld, AnneDroogh, Marjoes et al.Mirtazapine or ondansetron for hyperemesis gravidarum. A randomized placebo-controlled trial. American Journal of Obstetrics & Gynecology, June 2026","meta_description":"Hyperemesis gravidarum (HG) represents the most severe end of the nausea and vomiting of pregnancy spectrum. It has a reported incidence of approximately…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1332,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/dr-chapa-s-obgyn-no-spin-podcast-7407953/episodes/vomit-trial-mirtazapine-vs-ondansetron-for-hg/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/dr-chapa-s-obgyn-no-spin-podcast-7407953/vomit-trial-mirtazapine-vs-ondansetron-for-hg.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}