{"podcast":{"title":"Channel Your Enthusiasm","slug":"channel-your-enthusiasm-1374325","podcast_index_feed_id":1374325,"rss_url":"http://www.rosebook.club/episodes/?format=rss","website_url":"http://www.rosebook.club/episodes/","image_url":"https://images.squarespace-cdn.com/content/v1/548bc7f6e4b0a269c594ebc2/1611689941077-BL32D22Z1P27G4UAVKEE/Screen+Shot+2021-01-26+at+2.34.41+PM.png?format=1500w","author":"joel topf","episode_count":31,"summary":"A chapter by chapter recap of Burton Rose’s classic, The Clinical Physiology of Acid Base and Electrolyte Disorders, a kidney physiology book for nephrologists, fellows, residents and medical students.","last_synced_at":null,"page_url":"https://stenobird.com/podcast/channel-your-enthusiasm-1374325"},"episode":{"title":"Chapter Seventeen: Introduction to Simple and Mixed Acid-Base Disorders","slug":"chapter-seventeen-introduction-to-simple-and-mixed-acid-base-disorders","published_at":"2025-02-21T15:20:12+00:00","page_url":"https://stenobird.com/podcast/channel-your-enthusiasm-1374325/chapter-seventeen-introduction-to-simple-and-mixed-acid-base-disorders","show_page_url":"https://stenobird.com/podcast/channel-your-enthusiasm-1374325","url":"http://www.rosebook.club/episodes/2025/2/21/chapter-seventeen","audio_url":"https://static1.squarespace.com/static/548bc7f6e4b0a269c594ebc2/t/67b89808ae25812d8228e11b/1742745103251/Chapter+17+Intro+to+Acid-Base.mp3","summary":"References I said I used MDCalc but I was mistaken I use MedCalX which is nice but getting dated.  We talked about this out of print book that we love: Cohen, J. J., Kassirer, J. P. (1982). Acid-base. United States: Little, Brown. Josh mentioned this article that looked at over 17,000 samples with simultaneous measured and calculated bicarbonate and found a very small difference. Comparison of Measured and Calculated Bicarbonate Values | Clinical Chemistry | Oxford Academic Base deficit or excess- Diagnostic Use of Base Excess in Acid–Base Disorders | NEJM (check out the accompanying letter to the editor from Melanie challenging this article! Along with colleagues Lecker and Zeidel Diagnostic Use of Base Excess in Acid-Base Disorders ) Melanie loves this paper which shows a nice correlation between arterial and venous pH but the rest of the comparisons are disappointing - Comparison of arterial and venous pH, bicarbonate, Pco2 and Po2 in initial emergency department assessment - PMC A nomogram for the interpretation of acid-base data is figure 17-1 in the book, this manuscript with the ! in the conclusion creates the acid-base map.  We debated about whether we like Winter’s formula: Quantitative displacement of acid-base equilibrium in metabolic acidosis (melanie does b/c it used real patients).  Amy’s Voice of God on Dietary Acid Load Review of dietary acid load: https://pubmed.ncbi.nlm.nih.gov/23439373/ , https://pubmed.ncbi.nlm.nih.gov/38282081/ , https://pubmed.ncbi.nlm.nih.gov/33075387/ Survey data from kidney stone formers regarding sources of dietary acid load: https://pubmed.ncbi.nlm.nih.gov/35752401/ Urine profile for vegans and omnivories (urine pH and cations/anions): https://pubmed.ncbi.nlm.nih.gov/36364731/ SWAP-MEAT pilot trial: https://pub…","meta_description":"References I said I used MDCalc but I was mistaken I use MedCalX which is nice but getting dated. We talked about this out of print book that we lov…","key_points":[],"chapters":[],"topics":[],"duration_seconds":5509,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/channel-your-enthusiasm-1374325/episodes/chapter-seventeen-introduction-to-simple-and-mixed-acid-base-disorders/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/channel-your-enthusiasm-1374325/chapter-seventeen-introduction-to-simple-and-mixed-acid-base-disorders.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}