{"podcast":{"title":"Channel Your Enthusiasm","slug":"channel-your-enthusiasm-1374325","podcast_index_feed_id":1374325,"rss_url":"http://www.rosebook.club/episodes/?format=rss","website_url":"http://www.rosebook.club/episodes/","image_url":"https://images.squarespace-cdn.com/content/v1/548bc7f6e4b0a269c594ebc2/1611689941077-BL32D22Z1P27G4UAVKEE/Screen+Shot+2021-01-26+at+2.34.41+PM.png?format=1500w","author":"joel topf","episode_count":31,"summary":"A chapter by chapter recap of Burton Rose’s classic, The Clinical Physiology of Acid Base and Electrolyte Disorders, a kidney physiology book for nephrologists, fellows, residents and medical students.","last_synced_at":null,"page_url":"https://stenobird.com/podcast/channel-your-enthusiasm-1374325"},"episode":{"title":"Chapter Eleven: Regulation of Acid-Base Balance, part 1","slug":"chapter-eleven-regulation-of-acid-base-balance-part-1","published_at":"2023-02-12T23:01:25+00:00","page_url":"https://stenobird.com/podcast/channel-your-enthusiasm-1374325/chapter-eleven-regulation-of-acid-base-balance-part-1","show_page_url":"https://stenobird.com/podcast/channel-your-enthusiasm-1374325","url":"http://www.rosebook.club/episodes/2023/2/12/chapter-eleven-part-one","audio_url":"https://chrt.fm/track/47G747/static1.squarespace.com/static/548bc7f6e4b0a269c594ebc2/t/63e96dbd76653e35fab637d0/1677955516439/Chapter+11+part+1.mp3","summary":"References We considered the effect of a high protein diet and potential metabolic acidosis on kidney function. This review is of interest by Donald Wesson, a champion for addressing this issue and limiting animal protein: Mechanisms of Metabolic Acidosis-Induced Kidney Injury in Chronic Kidney Disease Hostetter explored the effect of a high protein diet in the remnant kidney model with 1 ¾ nephrectomy. Rats with reduced dietary acid load (by bicarbonate supplementation) had less tubular damage. Chronic effects of dietary protein in the rat with intact and reduced renal mass Wesson explored treatment of metabolic acidosis in humans with stage 3 CKD in this study. Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rate In addition to the effect of metabolic acidosis from a diet high in animal protein, this diet also leads to hyperfiltration. This was demonstrated in normal subjects;  ingesting a protein diet had a significantly higher creatinine clearance than a comparable group of normal subjects ingesting a vegetarian diet.    Renal functional reserve in humans: Effect of protein intake on glomerular filtration rate .This finding has been implicated in Brenner’s theory regarding hyperfiltration: The hyperfiltration theory: a paradigm shift in nephrology One of multiple publications from Dr. Nimrat Goraya whom Joel mentioned in the voice over: Dietary Protein as Kidney Protection: Quality or Quantity? We wondered about the time course in buffering a high protein meal (and its subsequent acid load on ventilation) and Amy found this report: Effect of Protein Intake on Ventilatory Drive | Anesthesiology | American Soc…","meta_description":"References We considered the effect of a high protein diet and potential metabolic acidosis on kidney function. This review is of interest by Donald Wesso…","key_points":[],"chapters":[],"topics":[],"duration_seconds":5824,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/channel-your-enthusiasm-1374325/episodes/chapter-eleven-regulation-of-acid-base-balance-part-1/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/channel-your-enthusiasm-1374325/chapter-eleven-regulation-of-acid-base-balance-part-1.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}