{"podcast":{"title":"Blood Podcast","slug":"blood-podcast-664776","podcast_index_feed_id":664776,"rss_url":"https://feeds.transistor.fm/blood-podcast","website_url":null,"image_url":"https://img.transistorcdn.com/WlMZsA1edpS0qEIavlrh9KLfCFShKE7FTJxZLlZsByw/rs:fill:0:0:1/w:1400/h:1400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9kY2Q4/YzJhZmMwODBjOWRi/YTNhN2Y1NWJkMzMw/NTBjZi5qcGc.jpg","author":"American Society of Hematology","episode_count":388,"summary":"The Blood Podcast summarizes content recently published in Blood, the most cited peer-reviewed publication in the field of hematology.","last_synced_at":"2026-07-17T04:20:44.828596+00:00","page_url":"https://stenobird.com/podcast/blood-podcast-664776"},"episode":{"title":"Pathophysiology of ANKRD26-related thrombocytopenia and B-ALL recurrence after blinatumomab","slug":"pathophysiology-of-ankrd26-related-thrombocytopenia-and-b-all-recurrence-after-blinatumomab","published_at":"2026-04-23T16:00:00+00:00","page_url":"https://stenobird.com/podcast/blood-podcast-664776/pathophysiology-of-ankrd26-related-thrombocytopenia-and-b-all-recurrence-after-blinatumomab","show_page_url":"https://stenobird.com/podcast/blood-podcast-664776","url":"https://share.transistor.fm/s/f867a52e","audio_url":"https://prfx.byspotify.com/e/media.transistor.fm/f867a52e/d7907794.mp3","summary":"In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Shengwen Calvin Li and Hrishi Krishna Srinagesh on their latest articles published in Blood . Dr. Li discusses \" Single-cell profiling of ANKRD26 thrombocytopenia reveals progenitor expansion and polyploid apoptosis via JUNB-p21 \". The study identifies reproducible abnormalities in progenitor expansion and increased apoptosis of polyploid megakaryocytes, and they propose a novel mechanism in which centrosomal over-expression of ANKRD26 drives polyploid megakaryocyte apoptosis through JUNB-mediated induction of p21 transcription. Dr. Srinagesh discusses \" Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL \" in which data collected by the Real-World Outcomes Collaborative of CAR-T in Adult ALL consortium showed that prior nonresponse to blinatumomab was associated with inferior survival after brexucabtagene in comparison to blinatumomab-naïve patients. Early CAR-T responses were uniformly high regardless of prior exposure or response. This highlights that resistance to blinatumomab may identify patients at higher risk of post–CAR T relapse despite excellent initial responses.","meta_description":"In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Shengwen Calvin Li and Hrishi Krishna Srinagesh on their latest articles published in…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1164,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/blood-podcast-664776/episodes/pathophysiology-of-ankrd26-related-thrombocytopenia-and-b-all-recurrence-after-blinatumomab/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/blood-podcast-664776/pathophysiology-of-ankrd26-related-thrombocytopenia-and-b-all-recurrence-after-blinatumomab.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}