{"podcast":{"title":"BioTalk Unzipped","slug":"biotalk-unzipped-6702602","podcast_index_feed_id":6702602,"rss_url":"https://feeds.captivate.fm/biotalk-unzipped/","website_url":"https://www.biotalkunzipped.com","image_url":"https://artwork.captivate.fm/bc8c17ac-b08b-4ac4-b89d-c3f29318523c/updated-BioTalk-Logo.png","author":"Gregory Austin","episode_count":46,"summary":"BioTalk Unzipped, hosted by Gregory Austin and Dr. Chad Briscoe, unzips the stories behind medical progress through candid, intelligent, and often entertaining conversations with leaders across biotechnology, pharmaceuticals, medical technology, clinical research, bioanalysis, and drug development. Each episode explores the science, strategy, setbacks, breakthroughs, and human stories shaping the future of medicine. From first-in-human trials and biomarkers to oncology, rare disease, AI, regulatory strategy, and emerging therapeutic technologies, BioTalk Unzipped makes complex life science topics engaging, accessible, and relevant. The show feels like the conversation you would want to overhear after a great scientific conference: thoughtful, unscripted, curious, and grounded in real-world experience. We bring listeners inside the decisions, discoveries, and personal journeys behind the therapies and technologies that may one day reduce suffering and improve lives.","last_synced_at":"2026-09-11T10:23:01.173868+00:00","page_url":"https://stenobird.com/podcast/biotalk-unzipped-6702602"},"episode":{"title":"Why Gene Therapy Is Still So Hard to Manufacture at Scale | Phillip Ramsey","slug":"why-gene-therapy-is-still-so-hard-to-manufacture-at-scale-phillip-ramsey","published_at":"2026-08-08T17:00:00+00:00","page_url":"https://stenobird.com/podcast/biotalk-unzipped-6702602/why-gene-therapy-is-still-so-hard-to-manufacture-at-scale-phillip-ramsey","show_page_url":"https://stenobird.com/podcast/biotalk-unzipped-6702602","url":"https://biotalk-unzipped.captivate.fm/episode/gene-therapy-manufacturing-scale-up","audio_url":"https://episodes.captivate.fm/episode/3768da98-507a-40ee-ad23-7047d52fefe5.mp3","summary":"Why is gene therapy still so difficult to manufacture at scale after decades of progress? Phillip Ramsey, Chief Technical Officer at Sangamo Therapeutics, joins BioTalk Unzipped for a candid conversation about one of the central challenges facing advanced therapies: turning extraordinary science into reproducible, scalable medicines. Thank You to Our Sponsors Leucentra - https://leucentra.com/ Inspired by Science. Empowered by IT. Leucentra provides specialized IT consulting and services for life sciences and healthcare, helping organizations use technology more effectively to support innovation. TruTechnologies - https://trutechnologies.ai/ Clinical Trial Execution, Live. TruTechnologies provides live clinical trial execution technology that gives sponsors greater visibility into protocol activities, samples, and study data as they happen. About This Episode Recorded onsite at the AAPS National Biotechnology Conference in Boston, Phillip explains why gene therapy manufacturing has not yet reached the maturity of monoclonal antibody production. As technologies have evolved across retroviral vectors, lentiviral vectors, adenovirus, AAV, lipid nanoparticles, and other advanced modalities, development teams have repeatedly been required to rethink fundamental manufacturing and analytical questions. Phillip discusses why analytics are critical, why experience across multiple manufacturing lots and products matters, and why there simply is no shortcut to developing the scientific knowledge necessary to manufacture advanced therapies reliably. He also reflects on the uncertainty of biotechnology. Early in his career, Phillip was walking down a hallway when his CFO asked if he had cashed his paycheck. When he said no, she told him not to. It's a remarkable story that captures…","meta_description":"Why is gene therapy still so difficult to manufacture at scale after decades of progress? Phillip Ramsey, Chief Technical Officer at Sangamo Therapeutics,…","key_points":[],"chapters":[],"topics":[],"duration_seconds":685,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/biotalk-unzipped-6702602/episodes/why-gene-therapy-is-still-so-hard-to-manufacture-at-scale-phillip-ramsey/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/biotalk-unzipped-6702602/why-gene-therapy-is-still-so-hard-to-manufacture-at-scale-phillip-ramsey.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}