{"podcast":{"title":"BioTalk Unzipped","slug":"biotalk-unzipped-6702602","podcast_index_feed_id":6702602,"rss_url":"https://feeds.captivate.fm/biotalk-unzipped/","website_url":"https://www.biotalkunzipped.com","image_url":"https://artwork.captivate.fm/bc8c17ac-b08b-4ac4-b89d-c3f29318523c/updated-BioTalk-Logo.png","author":"Gregory Austin","episode_count":43,"summary":"BioTalk Unzipped, hosted by Gregory Austin and Dr. Chad Briscoe, unzips the stories behind medical progress through candid, intelligent, and often entertaining conversations with leaders across biotechnology, pharmaceuticals, medical technology, clinical research, bioanalysis, and drug development. Each episode explores the science, strategy, setbacks, breakthroughs, and human stories shaping the future of medicine. From first-in-human trials and biomarkers to oncology, rare disease, AI, regulatory strategy, and emerging therapeutic technologies, BioTalk Unzipped makes complex life science topics engaging, accessible, and relevant. The show feels like the conversation you would want to overhear after a great scientific conference: thoughtful, unscripted, curious, and grounded in real-world experience. We bring listeners inside the decisions, discoveries, and personal journeys behind the therapies and technologies that may one day reduce suffering and improve lives.","last_synced_at":"2026-06-12T10:17:58.642598+00:00","page_url":"https://stenobird.com/podcast/biotalk-unzipped-6702602"},"episode":{"title":"Fail Fast, Learn Faster: Drug Development in Rare Disease with Dr. Binodh DeSilva","slug":"fail-fast-learn-faster-drug-development-in-rare-disease-with-dr-binodh-desilva","published_at":"2025-10-23T09:30:00+00:00","page_url":"https://stenobird.com/podcast/biotalk-unzipped-6702602/fail-fast-learn-faster-drug-development-in-rare-disease-with-dr-binodh-desilva","show_page_url":"https://stenobird.com/podcast/biotalk-unzipped-6702602","url":"https://biotalk-unzipped.captivate.fm/episode/fail-fast-learn-faster-binodh-desilva-rare-disease-drug-development","audio_url":"https://episodes.captivate.fm/episode/9c68d267-ba72-41e7-83a8-afd83c6410ea.mp3","summary":"In this episode of BioTalk Unzipped, Gregory Austin and Dr. Chad Briscoe sit down with Dr. Binodh DeSilva, Senior Vice President of Bioanalysis at Ultragenyx Pharmaceutical, to explore the science and soul behind rare-disease drug development. From her early days studying electrochemistry at the University of Kansas to leading cutting-edge bioanalytical programs at Ultragenyx, Dr. DeSilva shares how curiosity and community shaped her four-decade career. She discusses the profound responsibility of working with limited, often irreplaceable patient samples with care. A special thanks to AAPS ( https://www.aaps.org/ ) for their help and support of this episode. The conversation dives into: Balancing rigor and agility in small-population clinical studies Leveraging entrepreneurial mindsets from biotech within big pharma frameworks The promise of dried blood spots (DBS) and patient-centric sampling Mentorship, curiosity, and the future of scientific leadership Her return to Sri Lanka with KU faculty to recruit the next generation of scientists Throughout the discussion, DeSilva underscores a recurring theme: science thrives when curiosity meets compassion. This episode is a masterclass in both. Guest Links Dr. Binodh DeSilva https://www.linkedin.com/in/binodh-desilva/ Ultragenyx Pharmaceuticals - https://www.ultragenyx.com/   Hosts Dr. Chad Briscoe https://www.linkedin.com/in/chadbriscoe/   Celerion - https://www.celerion.com/    Gregory Austin https://www.linkedin.com/in/gregoryaustin1/   Celerion - https://www.celerion.com/    Keywords: BioTalk Unzipped, Binodh DeSilva, Ultragenyx, rare disease research, bioanalysis, dynamic drug development, dried blood spots, DBS sampling, biologics, AAPS NBC 2025, Gregory Austin, Chad Briscoe, Celerio…","meta_description":"In this episode of BioTalk Unzipped, Gregory Austin and Dr. Chad Briscoe sit down with Dr. Binodh DeSilva, Senior Vice President of Bioanalysis at Ultrage…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1888,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/biotalk-unzipped-6702602/episodes/fail-fast-learn-faster-drug-development-in-rare-disease-with-dr-binodh-desilva/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/biotalk-unzipped-6702602/fail-fast-learn-faster-drug-development-in-rare-disease-with-dr-binodh-desilva.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}