{"podcast":{"title":"BioTalk Unzipped","slug":"biotalk-unzipped-6702602","podcast_index_feed_id":6702602,"rss_url":"https://feeds.captivate.fm/biotalk-unzipped/","website_url":"https://www.biotalkunzipped.com","image_url":"https://artwork.captivate.fm/bc8c17ac-b08b-4ac4-b89d-c3f29318523c/updated-BioTalk-Logo.png","author":"Gregory Austin","episode_count":46,"summary":"BioTalk Unzipped, hosted by Gregory Austin and Dr. Chad Briscoe, unzips the stories behind medical progress through candid, intelligent, and often entertaining conversations with leaders across biotechnology, pharmaceuticals, medical technology, clinical research, bioanalysis, and drug development. Each episode explores the science, strategy, setbacks, breakthroughs, and human stories shaping the future of medicine. From first-in-human trials and biomarkers to oncology, rare disease, AI, regulatory strategy, and emerging therapeutic technologies, BioTalk Unzipped makes complex life science topics engaging, accessible, and relevant. The show feels like the conversation you would want to overhear after a great scientific conference: thoughtful, unscripted, curious, and grounded in real-world experience. We bring listeners inside the decisions, discoveries, and personal journeys behind the therapies and technologies that may one day reduce suffering and improve lives.","last_synced_at":"2026-09-11T10:23:01.173868+00:00","page_url":"https://stenobird.com/podcast/biotalk-unzipped-6702602"},"episode":{"title":"The Future of Dosing: Pharmacometrics, Oncology & Virtual Trials with Dr. Nathan Teuscher","slug":"collaborating-for-innovation-biopharma-success-with-dr-nathan-teuscher","published_at":"2025-01-20T15:00:00+00:00","page_url":"https://stenobird.com/podcast/biotalk-unzipped-6702602/collaborating-for-innovation-biopharma-success-with-dr-nathan-teuscher","show_page_url":"https://stenobird.com/podcast/biotalk-unzipped-6702602","url":"https://biotalk-unzipped.captivate.fm/episode/collaborating-for-innovation-biopharma-success-with-dr-nathan-teuscher","audio_url":"https://podcasts.captivate.fm/media/4a174c07-5fd9-41f1-80af-49813bed3178/https-3a-2f-2fd3ctxlq1ktw2nl-cloudfront-net-2fstaging-2f2025-0.mp3","summary":"In this episode of BioTalk Unzipped, Gregory Austin and Dr. Chad Briscoe continue their conversation with Dr. Nathan Teuscher, a clinical pharmacology and pharmacometrics expert with more than 20 years of experience in drug development. Nathan brings a clear, practical perspective on one of the most important questions in biopharma: how do we choose the right dose for the right patient, especially in complex areas like oncology and cell therapy? The conversation explores the changing landscape of pharmaceutical development, including virtual clinical trials, patient engagement, clinical pharmacology, pharmacometrics, oncology dose optimization, and the importance of collaboration across scientific disciplines. Nathan discusses why dose selection is not just a technical detail. It can shape safety, efficacy, patient experience, regulatory strategy, and ultimately whether a therapy succeeds. The episode also touches on FDA’s Project Optimus, the evolving expectations around oncology dosing, and the challenge of treating immunocompromised patients in areas such as cell therapy. The discussion also highlights how technology, data, and AI may help improve clinical trial design and patient selection, while still requiring thoughtful ethical judgment and scientific discipline. Nathan also shares advice for young scientists entering biopharma, including the importance of listening first, learning across disciplines, and approaching scientific collaboration with humility and curiosity. The episode closes with Nathan’s reflections on success, purpose, and his own Clinical Pharmacology Podcast, which helps educate listeners on clinical pharmacology, pharmacometrics, and drug development topics. In this episode Gregory, Chad, and Nathan discuss: The changing landscape of pharmaceu…","meta_description":"In this episode of BioTalk Unzipped, Gregory Austin and Dr. Chad Briscoe continue their conversation with Dr. Nathan Teuscher, a clinical pharmacology and…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1899,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/biotalk-unzipped-6702602/episodes/collaborating-for-innovation-biopharma-success-with-dr-nathan-teuscher/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/biotalk-unzipped-6702602/collaborating-for-innovation-biopharma-success-with-dr-nathan-teuscher.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}