{"podcast":{"title":"Biohacking Beauty: The Anti-Aging Skincare Podcast","slug":"biohacking-beauty-the-anti-aging-skincare-podcast-1375977","podcast_index_feed_id":1375977,"rss_url":"https://feeds.captivate.fm/biohacking-beauty/","website_url":"HTTPS://www.younggoose.com","image_url":"https://artwork.captivate.fm/298ca83b-8d04-48e9-9f13-64ac81e5b188/l62-_tnpsPe0KH5sj9Zklzmu.jpg","author":"Young Goose","episode_count":270,"summary":"Welcome to Biohacking Beauty, the definitive exploration of skin health through the lens of longevity medicine and cellular biology. Hosted by the founders of Young Goose, Amitay Eshel and Anastasia Khodzhaeva, this podcast moves beyond \"single-molecule\" trends to uncover the multi-mechanism protocols required to optimize the body’s largest organ. We bridge the gap between systemic longevity research and topical application. By hosting world-renowned experts in mitochondrial health, epigenetic signaling, and regenerative medicine, we translate complex research into actionable strategies for biological recalibration. From the 12 Hallmarks of Aging to the latest in bio-harmonizing lifestyle shifts, Biohacking Beauty provides the molecular tools and insights needed to align your skin’s appearance with your body’s peak biological potential.","last_synced_at":"2026-09-16T16:20:58.251623+00:00","page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977"},"episode":{"title":"Why Niacinamide Is Not the NAD+ Hero You Think It Is","slug":"why-niacinamide-is-not-the-nad-hero-you-think-it-is","published_at":"2026-04-22T08:00:00+00:00","page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/why-niacinamide-is-not-the-nad-hero-you-think-it-is","show_page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977","url":"HTTPS://www.younggoose.com","audio_url":"https://episodes.captivate.fm/episode/26fa2e77-dce3-433c-bd0a-979a559293e6.mp3","summary":"Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label. This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the mitochondrial support system most brands leave out. We also walk through the lifestyle levers that move the needle, and why one of them becomes non-negotiable for women after a certain age. If Part 1 explains what steals your NAD+, this episode is where the science gets practical and eye-opening. What's Discussed: (5:07) What the clinical data actually says about topical niacinamide (7:21) Why most niacinamide products on your shelf are underdosed (8:16) The roundabout pathway that makes niacinamide a poor NAD+ precursor (9:03) Niacinamide is a brightening agent, not an NAD+ booster (10:15) Why NMN can't cross the skin barrier alone (11:19) CD38 and blocking the enzyme that destroys NAD+ (13:03) NAD+ alone is potential energy, not usable energy (13:45) Liposomal encapsulation and how real precursors get into the skin (17:02) The five mitochondrial pathways your skin actually needs (18:53) Senescent cells and the next telomeres conversation (25:17) Why NAD Apex targets NAD+ in three dimensions (26:39) Lifestyle strategies: fasting and the AMPK pathway (28:47) How to get 30 to 50% more NAD+ from caloric restriction through fasting (30:37) The fun fact behind why 16:8 fasting became the standard (33:02) HIIT and its compounding effect on baseline NAD+ (34:51) Sleep is an NAD+ dependent repair session, not just rest (39:15) Your skin does 8x more renewal at night (41:38) Sun prote…","meta_description":"Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episo…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3584,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/episodes/why-niacinamide-is-not-the-nad-hero-you-think-it-is/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/why-niacinamide-is-not-the-nad-hero-you-think-it-is.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}