{"podcast":{"title":"Biohacking Beauty: The Anti-Aging Skincare Podcast","slug":"biohacking-beauty-the-anti-aging-skincare-podcast-1375977","podcast_index_feed_id":1375977,"rss_url":"https://feeds.captivate.fm/biohacking-beauty/","website_url":"HTTPS://www.younggoose.com","image_url":"https://artwork.captivate.fm/298ca83b-8d04-48e9-9f13-64ac81e5b188/l62-_tnpsPe0KH5sj9Zklzmu.jpg","author":"Young Goose","episode_count":270,"summary":"Welcome to Biohacking Beauty, the definitive exploration of skin health through the lens of longevity medicine and cellular biology. Hosted by the founders of Young Goose, Amitay Eshel and Anastasia Khodzhaeva, this podcast moves beyond \"single-molecule\" trends to uncover the multi-mechanism protocols required to optimize the body’s largest organ. We bridge the gap between systemic longevity research and topical application. By hosting world-renowned experts in mitochondrial health, epigenetic signaling, and regenerative medicine, we translate complex research into actionable strategies for biological recalibration. From the 12 Hallmarks of Aging to the latest in bio-harmonizing lifestyle shifts, Biohacking Beauty provides the molecular tools and insights needed to align your skin’s appearance with your body’s peak biological potential.","last_synced_at":"2026-09-16T16:20:58.251623+00:00","page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977"},"episode":{"title":"The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the Decline","slug":"the-nad-thief-your-skin-can-t-escape-cd38-zombie-cells-and-the-decline","published_at":"2026-04-08T08:00:00+00:00","page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/the-nad-thief-your-skin-can-t-escape-cd38-zombie-cells-and-the-decline","show_page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977","url":"HTTPS://www.younggoose.com","audio_url":"https://episodes.captivate.fm/episode/ad65d17d-ad26-48ef-afb6-ba715ab62d85.mp3","summary":"Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place. By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there. The enzyme your skin uses for DNA repair can wipe out up to 90% of what's left after a single afternoon in the sun. This isn't a slow, graceful decline. It's a collapse happening beneath the surface long before the wrinkles appear. In this episode, we will nerd out and break down exactly why NAD+ disappears, who the thieves are, and what the science actually says about getting it back. From the sirtuin-PARP-CD38 trifecta to the zombie cell feedback loop that accelerates the drain with age, this is the most complete picture of NAD+ and skin aging we've put together to date. We also cover the real differences between NMN, NR, and niacin, why the precursor you choose actually matters, and what to stack with it to protect your methylation pathways. Ready to nerd out in this with us? Let's dive in! What's Discussed: (4:00) The number that changes how you think about skin aging. (6:03) What NAD+ actually does and why \"rechargeable battery\" undersells it. (8:18) The three enzyme families consuming your NAD+ as a substrate. (8:23) Sirtuins: the police of your cells and what they cost you. (9:42) PARPs: the fire brigade and why one sunburn nearly wipes you out. (11:16) CD38: the NAD+ Pac-Man that gets worse with age. (15:10) The five-fold decline: what the 2012 tissue study actually found. (16:15) CD38 and the zombie cell feedback loop driving the decline. (19:39) What the depletion actually looks like in the mirror. (28:04) Why NAD+ decline is rever…","meta_description":"Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1940,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/episodes/the-nad-thief-your-skin-can-t-escape-cd38-zombie-cells-and-the-decline/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/the-nad-thief-your-skin-can-t-escape-cd38-zombie-cells-and-the-decline.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}