{"podcast":{"title":"Biohacking Beauty: The Anti-Aging Skincare Podcast","slug":"biohacking-beauty-the-anti-aging-skincare-podcast-1375977","podcast_index_feed_id":1375977,"rss_url":"https://feeds.captivate.fm/biohacking-beauty/","website_url":"HTTPS://www.younggoose.com","image_url":"https://artwork.captivate.fm/298ca83b-8d04-48e9-9f13-64ac81e5b188/l62-_tnpsPe0KH5sj9Zklzmu.jpg","author":"Young Goose","episode_count":270,"summary":"Welcome to Biohacking Beauty, the definitive exploration of skin health through the lens of longevity medicine and cellular biology. Hosted by the founders of Young Goose, Amitay Eshel and Anastasia Khodzhaeva, this podcast moves beyond \"single-molecule\" trends to uncover the multi-mechanism protocols required to optimize the body’s largest organ. We bridge the gap between systemic longevity research and topical application. By hosting world-renowned experts in mitochondrial health, epigenetic signaling, and regenerative medicine, we translate complex research into actionable strategies for biological recalibration. From the 12 Hallmarks of Aging to the latest in bio-harmonizing lifestyle shifts, Biohacking Beauty provides the molecular tools and insights needed to align your skin’s appearance with your body’s peak biological potential.","last_synced_at":"2026-09-16T16:20:58.251623+00:00","page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977"},"episode":{"title":"257. The Mitochondria Problem Behind Aging Skin + How to Recharge Your Skin and Look Younger","slug":"257-the-mitochondria-problem-behind-aging-skin-how-to-recharge-your-skin-and-look-younger","published_at":"2026-06-10T08:00:00+00:00","page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/257-the-mitochondria-problem-behind-aging-skin-how-to-recharge-your-skin-and-look-younger","show_page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977","url":"HTTPS://www.younggoose.com","audio_url":"https://episodes.captivate.fm/episode/bd8294f4-bfd0-46fd-aba3-8d21e0f908f6.mp3","summary":"Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail. In this solo episode, Young Goose co-founder Amitay Eshel breaks down the two sides of mitochondrial decline that drive skin aging and explains why the science-led skincare category has spent the last decades addressing only one of them. The first side of skin aging is where most skincare brands have built their products around. The other side is the one almost no skincare on the market is formulating for, and it is where the next chapter of skin longevity is being written. If you have outgrown the antioxidant-and-peptide era of skincare and want to understand what is actually happening underneath your skin as it ages, this episode is for you. What's Discussed: (01:35) The 2-billion-year-old contract inside every skin cell that is now fraying. (04:10) Why skin is one of the most mitochondria-dense organs in your body. (08:20) The 2012 paper that showed NAD drops by half between 35 and 70. (13:15) How a refugee fired in 1933 figured out the chemistry your cream still runs on. (16:30) The second half of the decline almost no skincare addresses. (19:45) The master regulator that decides whether your cells can hire. (24:00) The two columns of mitochondrial biology and why most brands only work in one. (32:10) Why this is a ten-year strategy, not a two-week one. Resources Mentioned: Download the Cellular Energy Protocol: https://www.younggoose.com/pages/the-mitochondrial-skin-stack Age-Associated Changes in Oxidative Stress and NAD+ Study: jour…","meta_description":"Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants o…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2070,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/episodes/257-the-mitochondria-problem-behind-aging-skin-how-to-recharge-your-skin-and-look-younger/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/257-the-mitochondria-problem-behind-aging-skin-how-to-recharge-your-skin-and-look-younger.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}