{"podcast":{"title":"Behind the Genes","slug":"behind-the-genes-3509739","podcast_index_feed_id":3509739,"rss_url":"https://feed.podbean.com/genomicsengland/feed.xml","website_url":"https://genomicsengland.podbean.com","image_url":"https://pbcdn1.podbean.com/imglogo/image-logo/10639619/CopyofBehindtheGenestemplates_g5qetz.png","author":"Genomics England","episode_count":100,"summary":"At Genomics England, our vision is a world where everyone benefits from genomic healthcare. From the latest research to the lived experiences of those affected by rare conditions and cancer, Behind the Genes brings you closer to the people behind the science. Each month, we release a deep-dive episode, alongside our Genomics 101 series - short explainers designed to make complex terms in genetics and genomics easier to understand.","last_synced_at":"2026-07-15T16:17:03.922225+00:00","page_url":"https://stenobird.com/podcast/behind-the-genes-3509739"},"episode":{"title":"How can genomics help us understand rare conditions?","slug":"how-can-genomics-help-us-understand-rare-conditions","published_at":"2026-06-10T07:00:00+00:00","page_url":"https://stenobird.com/podcast/behind-the-genes-3509739/how-can-genomics-help-us-understand-rare-conditions","show_page_url":"https://stenobird.com/podcast/behind-the-genes-3509739","url":"https://genomicsengland.podbean.com/e/how-can-genomics-help-us-understand-rare-conditions/","audio_url":"https://mcdn.podbean.com/mf/web/ghqvcnuqiyg3sdt7/Gen_101_Jamie_final_mix_mp39zxmz.mp3","summary":"In this explainer episode, we’ve asked Jamie Ellingford, Lead Genomic Data Scientist for Rare Disease, to explain how genomics is helping us better understand rare conditions. You can also find a series of short videos explaining some of the common terms you might encounter about genomics on our YouTube channel. If you’ve got any questions, or have any other topics you’d like us to explain, let us know on podcast@genomicsengland.co.uk. You can download the transcript or read it below. [00:00:00] Florence: How can genomics help us better understand rare conditions? My name is Florence Cornish, and today I am joined by our Lead Genomic Data Scientist for Rare Disease, Jamie Ellingford, and he is going to be sharing lots more insights about the topic with us. So, I guess before we begin, Jamie, it might be useful if you could explain what we actually mean by the term 'rare condition'? [00:00:25] Jamie: Sure. Hi, Florence. So, a rare condition we define as something that impacts one in less than two thousand people, and so that's something that occurs really infrequently in the population. But we know that collectively there's lots of different rare diseases. And so, the estimates are that it's about one in seventeen people in the population that are impacted by some sort of rare disease, of which we think there's over seven thousand. But research that uses data that we have here at Genomics England as well as other sources is starting to uncover more and more of these individual rare disorders. So collectively, as I just said, one in seventeen individuals, we think, is impacted by a rare disease, and that equates to almost three and a half million people here in the UK. [00:01:15] Most of these rare conditions, we think, have a genetic basis, and perhaps we'll explain a l…","meta_description":"In this explainer episode, we’ve asked Jamie Ellingford, Lead Genomic Data Scientist for Rare Disease, to explain how genomics is helping us better unders…","key_points":[],"chapters":[],"topics":[],"duration_seconds":608,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/behind-the-genes-3509739/episodes/how-can-genomics-help-us-understand-rare-conditions/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/behind-the-genes-3509739/how-can-genomics-help-us-understand-rare-conditions.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}