{"podcast":{"title":"Behind the Breakthroughs","slug":"behind-the-breakthroughs-7055075","podcast_index_feed_id":7055075,"rss_url":"https://feeds.acast.com/public/shows/67105af848726944170ab1fe","website_url":"https://shows.acast.com/behind-the-breakthroughs-by-inside-precision-medicine","image_url":"https://assets.pippa.io/shows/67105af848726944170ab1fe/1729176633209-4c042f7e-c9b1-44c7-b2f0-3d36b4c78148.jpeg","author":"Inside Precision Medicine","episode_count":46,"summary":"Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine , as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and care. In every episode, Jonathan goes beyond the science, diving deep into the personal and professional journeys of those striving to make these incredible new therapies more equitable and accessible globally. You'll discover how emerging technologies in molecular diagnostics, next-generation sequencing, genetic medicines (e.g., cell and gene therapies), and AI/ML are transforming treatment and bringing precision medicine closer to the forefront of healthcare. Whether you’re a researcher at a large pharma company or small biotech startup, a clinician at a major health system or community setting, a laboratory technician in the clinic or academia, an investor at a premier or venture capital firm, or just interested in the latest in medicine and healthcare, these interviews will inspire an…","last_synced_at":"2026-07-15T16:19:49.218663+00:00","page_url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075"},"episode":{"title":"Zachary Roberts: Building a Viable Off-the-Shelf CAR T","slug":"zachary-roberts-building-a-viable-off-the-shelf-car-t","published_at":"2026-01-28T08:01:00+00:00","page_url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075/zachary-roberts-building-a-viable-off-the-shelf-car-t","show_page_url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075","url":"https://shows.acast.com/behind-the-breakthroughs-by-inside-precision-medicine/episodes/zachary-roberts-building-a-viable-off-the-shelf-car-t","audio_url":"https://sphinx.acast.com/p/open/s/67105af848726944170ab1fe/e/6978f145e23c68f310a991a6/media.mp3","summary":"Cancer immunotherapy evolved through decades of research, with watershed moments like checkpoint inhibitor approvals and the first CAR T trial results reshaping expectations. For Zachary Roberts, MD, PhD, witnessing CAR T-induced remissions as a Mass General resident convinced him of the field’s future and drew him from academia into drug development. Now as CMO and EVP of R&D at Allogene Therapeutics, he’s focused on the next inflection point: transforming CAR T into scalable, off-the-shelf therapies that could broaden access and extend impact beyond cancer to autoimmune disease. Produced and hosted by Jonathan D. Grinstein, PhD Audio mixed and mastered by Erick Ziegler Brought to you by Inside Precision Medicine (SAGE Publishing) Hosted on Acast. See acast.com/privacy for more information.","meta_description":"Cancer immunotherapy evolved through decades of research, with watershed moments like checkpoint inhibitor approvals and the first CAR T trial results res…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3374,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/behind-the-breakthroughs-7055075/episodes/zachary-roberts-building-a-viable-off-the-shelf-car-t/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075/zachary-roberts-building-a-viable-off-the-shelf-car-t.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}