{"podcast":{"title":"Behind the Breakthroughs","slug":"behind-the-breakthroughs-7055075","podcast_index_feed_id":7055075,"rss_url":"https://feeds.acast.com/public/shows/67105af848726944170ab1fe","website_url":"https://shows.acast.com/behind-the-breakthroughs-by-inside-precision-medicine","image_url":"https://assets.pippa.io/shows/67105af848726944170ab1fe/1729176633209-4c042f7e-c9b1-44c7-b2f0-3d36b4c78148.jpeg","author":"Inside Precision Medicine","episode_count":46,"summary":"Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine , as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and care. In every episode, Jonathan goes beyond the science, diving deep into the personal and professional journeys of those striving to make these incredible new therapies more equitable and accessible globally. You'll discover how emerging technologies in molecular diagnostics, next-generation sequencing, genetic medicines (e.g., cell and gene therapies), and AI/ML are transforming treatment and bringing precision medicine closer to the forefront of healthcare. Whether you’re a researcher at a large pharma company or small biotech startup, a clinician at a major health system or community setting, a laboratory technician in the clinic or academia, an investor at a premier or venture capital firm, or just interested in the latest in medicine and healthcare, these interviews will inspire an…","last_synced_at":"2026-07-15T16:19:49.218663+00:00","page_url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075"},"episode":{"title":"Markus Warmuth: Eliminating Pathogenic Proteins with Molecular Glue Degraders","slug":"markus-warmuth-eliminating-pathogenic-proteins-with-molecular-glue-degraders","published_at":"2026-03-11T07:01:00+00:00","page_url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075/markus-warmuth-eliminating-pathogenic-proteins-with-molecular-glue-degraders","show_page_url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075","url":"https://shows.acast.com/behind-the-breakthroughs-by-inside-precision-medicine/episodes/markus-warmuth-eliminating-pathogenic-proteins-with-molecula","audio_url":"https://sphinx.acast.com/p/open/s/67105af848726944170ab1fe/e/69ab36ebb49eecc0b7c39b2a/media.mp3","summary":"Traditional drugs usually inhibit specific protein sites, but many disease-causing proteins lack accessible or unique motifs, leaving them “undruggable.” Targeted Small-molecule drugs have long been the quiet workhorses of modern medicine, slipping inside cells to target disease-driving proteins, even as biologics, immunotherapies, and genetic medicines have taken center stage in recent years. Yet thousands of disease-related proteins remain “undruggable” because they lack the structural pockets needed for traditional inhibitors to bind. In this episode, Markus Warmuth, MD, CEO of Monte Rosa Therapeutics, explains how molecular glue degraders harness the cell’s protein-disposal machinery to eliminate harmful proteins entirely, and how the company’s QUEEN discovery platform is advancing new therapies in cancer and autoimmune disease. Produced and hosted by Jonathan D. Grinstein, PhD Audio mixed and mastered by Erick Ziegler Brought to you by Inside Precision Medicine (SAGE Publishing) Hosted on Acast. See acast.com/privacy for more information.","meta_description":"Traditional drugs usually inhibit specific protein sites, but many disease-causing proteins lack accessible or unique motifs, leaving them “undruggable.”…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2903,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/behind-the-breakthroughs-7055075/episodes/markus-warmuth-eliminating-pathogenic-proteins-with-molecular-glue-degraders/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075/markus-warmuth-eliminating-pathogenic-proteins-with-molecular-glue-degraders.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}