{"podcast":{"title":"Behind the Breakthroughs","slug":"behind-the-breakthroughs-7055075","podcast_index_feed_id":7055075,"rss_url":"https://feeds.acast.com/public/shows/67105af848726944170ab1fe","website_url":"https://shows.acast.com/behind-the-breakthroughs-by-inside-precision-medicine","image_url":"https://assets.pippa.io/shows/67105af848726944170ab1fe/1729176633209-4c042f7e-c9b1-44c7-b2f0-3d36b4c78148.jpeg","author":"Inside Precision Medicine","episode_count":46,"summary":"Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine , as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and care. In every episode, Jonathan goes beyond the science, diving deep into the personal and professional journeys of those striving to make these incredible new therapies more equitable and accessible globally. You'll discover how emerging technologies in molecular diagnostics, next-generation sequencing, genetic medicines (e.g., cell and gene therapies), and AI/ML are transforming treatment and bringing precision medicine closer to the forefront of healthcare. Whether you’re a researcher at a large pharma company or small biotech startup, a clinician at a major health system or community setting, a laboratory technician in the clinic or academia, an investor at a premier or venture capital firm, or just interested in the latest in medicine and healthcare, these interviews will inspire an…","last_synced_at":"2026-07-15T16:19:49.218663+00:00","page_url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075"},"episode":{"title":"Amber Salzman: Epigenetic Editing Aims to Refine Personalized Genetic Medicine","slug":"amber-salzman-epigenetic-editing-aims-to-refine-personalized-genetic-medicine","published_at":"2025-07-23T07:00:00+00:00","page_url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075/amber-salzman-epigenetic-editing-aims-to-refine-personalized-genetic-medicine","show_page_url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075","url":"https://shows.acast.com/behind-the-breakthroughs-by-inside-precision-medicine/episodes/uncut-gems-epigenetic-editing-aims-to-refine-personalized-ge","audio_url":"https://sphinx.acast.com/p/open/s/67105af848726944170ab1fe/e/688055b9498abee416ef990a/media.mp3","summary":"With recent safety setbacks in gene therapy underscoring the risks of genetic medicine, Amber Salzman, PhD, is charting a different course. After 25 years in big pharma, she now leads Epicrispr, where their Gene Expression Modulation System (GEMS) fine-tunes gene activity to tackle diseases too complex for traditional gene replacement, including Duchenne muscular dystrophy. On Behind the Breakthroughs , Salzman shares how epigenomic modulation could open new frontiers in treatment. Produced and hosted by Jonathan D. Grinstein, PhD Audio mixed and mastered by David Mosely Brought to you by Inside Precision Medicine (SAGE Publishing) Hosted on Acast. See acast.com/privacy for more information.","meta_description":"With recent safety setbacks in gene therapy underscoring the risks of genetic medicine, Amber Salzman, PhD, is charting a different course. After 25 years…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2457,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/behind-the-breakthroughs-7055075/episodes/amber-salzman-epigenetic-editing-aims-to-refine-personalized-genetic-medicine/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/behind-the-breakthroughs-7055075/amber-salzman-epigenetic-editing-aims-to-refine-personalized-genetic-medicine.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}