{"podcast":{"title":"Answers from the Lab","slug":"answers-from-the-lab-870296","podcast_index_feed_id":870296,"rss_url":"https://feeds.transistor.fm/answers-from-the-lab","website_url":"https://news.mayocliniclabs.com/podcast/answers-from-the-lab/","image_url":"https://img.transistorcdn.com/B9HbHcxSMFuy8GSjzQspBU_yr7OZ0kDg-c2slusbf14/rs:fill:0:0:1/w:1400/h:1400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9lYjNj/ZDc0NTE0MWNlOWRl/YzRiN2Q3NDg2Mjg5/YWE4MS5qcGc.jpg","author":"Mayo Clinic Laboratories","episode_count":383,"summary":"A Mayo Clinic curated podcast sharing Mayo Clinic knowledge and advancements on the state of testing, science, and people who are making it happen behind the scenes.","last_synced_at":"2026-06-11T16:18:30.710370+00:00","page_url":"https://stenobird.com/podcast/answers-from-the-lab-870296"},"episode":{"title":"Whole Exome Sequencing Reflex Test Offers Cost-Effective Diagnosis: Cherisse Marcou, Ph.D., and Kristen Rasmussen, M.S., CGC","slug":"whole-exome-sequencing-reflex-test-offers-cost-effective-diagnosis-cherisse-marcou-ph-d-and-kristen-rasmussen-m-s-cgc","published_at":"2025-09-02T06:00:00+00:00","page_url":"https://stenobird.com/podcast/answers-from-the-lab-870296/whole-exome-sequencing-reflex-test-offers-cost-effective-diagnosis-cherisse-marcou-ph-d-and-kristen-rasmussen-m-s-cgc","show_page_url":"https://stenobird.com/podcast/answers-from-the-lab-870296","url":"https://share.transistor.fm/s/34602bf7","audio_url":"https://media.transistor.fm/34602bf7/8f2218bf.mp3","summary":"Cherisse Marcou, Ph.D., and Kristen Rasmussen, M.S., CGC, explain how Mayo Clinic Laboratories' WESPR whole exome sequencing reflex test provides cost-effective diagnosis of complex genetic conditions. Using samples and data from previous targeted gene panels, WESPR's wider net can identify undetected genetic variants. (00:32) Would each of you share a little bit about yourselves and your background? (01:42) Could you provide us with an overview of the whole exome reflexing panel? (02:53) Is this different from our whole exome sequencing panel and our whole exome reanalysis panel? (04:00) Tell us more about who benefits from this test. (06:17) What is the clinical utility of this testing? (08:07) Would you help providers understand how to go about ordering? (11:23) Could you tell us more about the types of variants identified by this test? (13:39) Based on those performance characteristics, how does our test match up to other exome tests available in the market? (14:30) Are there any other unique features you would like to highlight? (15:57) What is the turnaround time for the reflex panel? (16:14) Can the results from the WESPR test be reanalyzed in the future as new genetic knowledge emerges? (16:56) How are variants reported, especially variants of uncertain significance? And does the report include recommendations? (19:31) Would you summarize the benefits of the WESPR at Mayo Clinic Laboratories?","meta_description":"Cherisse Marcou, Ph.D., and Kristen Rasmussen, M.S., CGC, explain how Mayo Clinic Laboratories' WESPR whole exome sequencing reflex test provides cost-eff…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1333,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/answers-from-the-lab-870296/episodes/whole-exome-sequencing-reflex-test-offers-cost-effective-diagnosis-cherisse-marcou-ph-d-and-kristen-rasmussen-m-s-cgc/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/answers-from-the-lab-870296/whole-exome-sequencing-reflex-test-offers-cost-effective-diagnosis-cherisse-marcou-ph-d-and-kristen-rasmussen-m-s-cgc.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}