# New Drug - THALASSINE-7 - Next Generation Psychedelic Compounds - Synthesis, Trip Report

Page: https://stenobird.com/podcast/truelife-753669/new-drug-thalassine-7-next-generation-psychedelic-compounds-synthesis-trip-report
Text version: https://stenobird.com/podcast/truelife-753669/new-drug-thalassine-7-next-generation-psychedelic-compounds-synthesis-trip-report.md
Podcast: [TrueLife](https://stenobird.com/podcast/truelife-753669)
Published: 2026-02-24T21:17:15+00:00
Episode link: https://share.transistor.fm/s/5ef6b5a1
Audio file: https://pdcn.co/e/pdst.fm/e/dts.podtrac.com/redirect.mp3/media.transistor.fm/5ef6b5a1/fd78f582.mp3
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JSON: https://stenobird.com/v1/public/podcasts/truelife-753669/episodes/new-drug-thalassine-7-next-generation-psychedelic-compounds-synthesis-trip-report
Duration seconds: 1215

## Resource

Support the show: https://www.paypal.me/Truelifepodcast?locale.x=en_US One on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meeting PSYCHEDELIC COMPOUNDS That No One Has Made But I Think I Would Love Episode Six: THALASSINE-7 (7-OH-Mitragynine-DMT Conjugate / Sigma-2 Agonist / Cortistatin Analog) “The compound that puts you in the water. The water that is already in you.” ✦ Episode Summary This episode delivers a haunting, second-person narrative of THALASSINE-7 , a purely theoretical psychedelic that doesn’t flood you with new visions — it turns up the volume on what your body is already screaming, clears the static of self-protection, and holds you in crystal-clear confrontation with the self at depth. Framed through a father and his nine-year-old daughter’s real-time fight against a rip current at Three Tables Beach on Oahu’s North Shore, the “trip” becomes an unflinching mirror for overconfidence, the weight of trust, ignoring warning signs, and the difference between survival and wisdom. The Compound (Theoretical Pharmacology) • Backbone : Modified 7-hydroxymitragynine redirected from opioid receptors to sigma-2 agonism (mitochondrial receptors that govern the cellular “continue or quit” decision — literally apoptosis/survival signaling). • Psychedelic Link : 5-substituted DMT moiety connected via sulfonyl linker, creating allosteric cross-talk that amplifies whatever signal your nervous system is already broadcasting instead of overlaying new hallucinations. • Rest Component : Cortistatin-14 analog — the same neuropeptide your brain releases in deep slow-wave sleep — brought into full waking consciousness to quiet hippocampal chatter and deliver profound, low-static rest while you remain completely alert. Net Effect : Complete wakefulness + t…

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