# Rocket’s Gene Therapy Trial Paused, Boltz-2 Open Source, Plasma Swap Rewinds Aging

Page: https://stenobird.com/podcast/touching-base-6714887/rocket-s-gene-therapy-trial-paused-boltz-2-open-source-plasma-swap-rewinds-aging
Text version: https://stenobird.com/podcast/touching-base-6714887/rocket-s-gene-therapy-trial-paused-boltz-2-open-source-plasma-swap-rewinds-aging.md
Podcast: [Touching Base](https://stenobird.com/podcast/touching-base-6714887)
Published: 2025-06-06T13:14:10+00:00
Episode link: https://shows.acast.com/touching-base/episodes/rockets-gene-therapy-trial-paused-boltz-2-open-source-plasma
Audio file: https://sphinx.acast.com/p/open/s/65736d39d32e730012c98919/e/6842e9401dd9d3b33f947c09/media.mp3
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JSON: https://stenobird.com/v1/public/podcasts/touching-base-6714887/episodes/rocket-s-gene-therapy-trial-paused-boltz-2-open-source-plasma-swap-rewinds-aging
Duration seconds: 1795

## Resource

A gene therapy clinical trial for Danon disease run by Rocket Pharmaceuticals has been suspended following the death of a patient. MIT and Recursion have released Boltz-2, an open-source tool that predicts molecular binding affinity at newfound speed and accuracy, aiming to democratize commercial drug discovery. Intellia Therapeutics saw its stock nosedive late last week after a patient in its Phase III trial of the CRISPR-based therapy experienced non-lethal liver toxicity. In other news, a therapeutic plasma exchange regimen combined with intravenous immunoglobulin reduced some biomarkers of biological age in humans. Sanofi has agreed to acquire Blueprint Medicines for up to $9.5 billion, and a universal CAR T cell therapy was produced by applying CRISPR gene editing to cells donated by healthy individuals.    Join GEN editors Corinna Singleman, PhD, Alex Philippidis, Fay Lin, PhD, and Uduak Thomas for a discussion of the latest biotech and biopharma news.     Listed below are links to the GEN stories referenced in this episode of Touching Base     Danon Disease Patient Dies in Rocket Gene Therapy Trial   By Alex Philippidis, GEN, May 27, 2025    Boltz-2 Released to Democratize AI Molecular Modeling for Drug Discovery   By Fay Lin, PhD, GENEdge, June 6, 2025    StockWatch: Intellia Stumbles on News of Patient’s Severe Liver Toxicity   By Alex Philippidis, GEN, May 30, 2025    The State of CRISPR Summit Registration  https://bit.ly/CRISPR25     Plasma Exchange in Humans Reduces Biological Age by Over Two Years   GEN, June 1, 2025     Sanofi to Acquire Blueprint Medicines for Up to $9.5B   By Alex Philippidis, GEN Edge, June 2, 2025    "Universal…

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