# E24: NMDA Receptor Antagonists: Ketamine, Esketamine (Spravato), and Dextromethorphan+Bupropion (Auvelity)

Page: https://stenobird.com/podcast/this-is-your-brain-on-drugs-psychiatry-podcast-7023342/e24-nmda-receptor-antagonists-ketamine-esketamine-spravato-and-dextromethorphan-bupropion-auvelity
Text version: https://stenobird.com/podcast/this-is-your-brain-on-drugs-psychiatry-podcast-7023342/e24-nmda-receptor-antagonists-ketamine-esketamine-spravato-and-dextromethorphan-bupropion-auvelity.md
Podcast: [This Is Your Brain On Drugs Psychiatry Podcast](https://stenobird.com/podcast/this-is-your-brain-on-drugs-psychiatry-podcast-7023342)
Published: 2025-01-30T17:08:09+00:00
Episode link: https://feeds.podcastle.ai/9cdee61e-55e2-42ea-a444-fa53266b8653/E24%20NMDAR%20Antagonists.mp3
Audio file: https://feeds.podcastle.ai/9cdee61e-55e2-42ea-a444-fa53266b8653/E24%20NMDAR%20Antagonists.mp3
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Duration seconds: 3674

## Resource

Today we have an interesting episode. We are covering the first of a very new class of antidepressants, the NMDA receptor antagonists. These are the first antidepressants approved for use for depression which do not interact with the monoamine system, and many more may be coming out in the future. We will talk about ketamine, its sister, esketamine, and the only oral form, a combination of the cough suppressant dextromethorphan and bupropion. Find out how this new class of antidepressant works for depression and what my opinion is of these new medications!

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## Transcript

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