# On whole-cell modeling of bacteria - with Markus Covert - #28

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Text version: https://stenobird.com/podcast/theoretical-neuroscience-podcast-6657149/on-whole-cell-modeling-of-bacteria-with-markus-covert-28.md
Podcast: [Theoretical Neuroscience Podcast](https://stenobird.com/podcast/theoretical-neuroscience-podcast-6657149)
Published: 2025-05-24T06:00:00+00:00
Episode link: https://431c9cd0-a1ff-4f9a-ac41-4fca68240d88.libsyn.com/on-whole-cell-modeling-of-bacteria-with-markus-covert-28
Audio file: https://traffic.libsyn.com/secure/431c9cd0-a1ff-4f9a-ac41-4fca68240d88/ThN-028-MarkusCovert_mixdown.mp3?dest-id=4181327
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Duration seconds: 7463

## Resource

A future computational neuroscience project could be to model not only the signal processing properties of neurons, but also all processes that keep a neuron alive for, say, a 100-year life span. In 2012 the group of the guest published the first such whole-cell model for a very simple bacterium (M. genitalia). In 2020 a model of the larger E. coli bacterium comprising 10.000 equations and 19.000 model parameters was presented. How are such models built, and what can they do?

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