# #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

Page: https://stenobird.com/podcast/the-tim-ferriss-show-739525/845-how-to-use-ketosis-for-enhanced-mood-cognition-and-long-term-brain-protection-a-practical-and-tactical-guide-with-dr-dominic-d-agostino-plus-deconstructing-tim-s-latest-keto-experiment
Text version: https://stenobird.com/podcast/the-tim-ferriss-show-739525/845-how-to-use-ketosis-for-enhanced-mood-cognition-and-long-term-brain-protection-a-practical-and-tactical-guide-with-dr-dominic-d-agostino-plus-deconstructing-tim-s-latest-keto-experiment.md
Podcast: [The Tim Ferriss Show](https://stenobird.com/podcast/the-tim-ferriss-show-739525)
Published: 2026-01-07T00:00:00+00:00
Episode link: https://rss.art19.com/episodes/488629b4-0090-4eed-a5bb-6f57ae38326f.mp3?rss_browser=BAhJIg90cmFuc2NyaWJyBjoGRVQ%3D--952c5701c84ad333c69d5faa668f8177091704f0
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Duration seconds: 8507

## Resource

Dr. Dominic D’Agostino  ( @DominicDAgosti2 ) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition. This episode is brought to you by: Gusto  simple and easy payroll, HR, and benefits platform used by 400,000+ businesses:   https://gusto.com/tim   Seed's DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic:  https://Seed.com/Tim   David Protein Bars   28g of protein, 150 calories, and 0g of sugar :  https://davidprotein.com/tim   Coyote the card game​ , which I co-created with Exploding Kittens:  https://coyotegame.com * Timestamps: [00:00:00] Who is Dominic D'Agostino? [00:04:37] Ketosis benefits: Quieting the mind, GABA elevation, metabolic psychiatry. [00:09:24] My Lyme disease story: Pseudo-dementia reversed in 3-4 days of ketosis. [00:13:50] Spirochetes are glycolytic: Starve the bug, boost the immune response. [00:19:20] Ketosis and cancer: Slowing glycolytic tumors, enhancing standard care. [00:20:50] My 18-day keto experiment: Mood stabilization, Alzheimer’s prevention hopes. [00:23:19] Metabolic memory: Carryover effects and Valter Longo’s fasting mimicking research. [00:27:11] Intermittent fasting as keto on-ramp: My 2-8 p.m. eating window. [00:29:15] Dom’s budget keto meal: Canned mackerel, MCT oil, apple cider vinegar. [00:33:28] My ketone measurement paradox: Feeling sharp at 0.2 mM readings. [00:36:56] The carburetor analogy: Ketone production vs. utilization explained. [00:38:43] Breath ketones vs. blood ketones: Better indicator in caloric deficit. [00:39:47] Gluconeogenesis fears: Fat, fiber, and sa…

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