# Genetic Pathways to Longevity: Harnessing Polygenic Risk Scores for Personalized Age-less Interventions

Page: https://stenobird.com/podcast/the-science-of-age-less-living-7235688/genetic-pathways-to-longevity-harnessing-polygenic-risk-scores-for-personalized-age-less-interventions
Text version: https://stenobird.com/podcast/the-science-of-age-less-living-7235688/genetic-pathways-to-longevity-harnessing-polygenic-risk-scores-for-personalized-age-less-interventions.md
Podcast: [The Science of Age-less Living](https://stenobird.com/podcast/the-science-of-age-less-living-7235688)
Published: 2025-09-06T19:09:17+00:00
Episode link: https://rss.com/podcasts/the-science-of-age-less-living/2202700
Audio file: https://content.rss.com/episodes/319089/2202700/the-science-of-age-less-living/2025_09_06_19_08_27_b13f3cc9-60c5-4879-b4d6-9d5081e1c26a.mp3
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Duration seconds: 1851

## Resource

Dive into polygenic risk scores (PRS) and discover how your genetic blueprint can inform personalized longevity strategies. Dr. Ethan Hausman-Marquis breaks down genome sequencing, five major genetic pathways to aging (DNA repair, metabolism, inflammation, mitochondria, neurodegeneration), and real-world clinical applications from The Catalyst Clinic. Learn how PRS can shift prevention from one-size-fits-all to truly individualized interventions—while understanding limits like population bias and probabilistic risk. Perfect for longevity science fans curious about precision medicine, NAD+, peptides, and building cognitive and mitochondrial resilience. If this episode helped you, please like and share with someone interested in age-less living. #PolygenicRiskScore #Longevity #PrecisionMedicine #AntiAging #Genomics OUTLINE: 00:00:00 Title and Introduction 00:02:35 Genes Aren't Destiny 00:06:19 What Is a Polygenic Risk Score? 00:10:28 Two Patients Example 00:13:17 Five Major Pathways 00:20:58 Limitations and Caveats 00:25:30 Clinical Application 00:27:56 Emotional Impact 00:29:58 Closing Reflection

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