# Episode 406: Drug Resistance Biomarkers and Their Impact on Cancer Treatment Choices Page: https://stenobird.com/podcast/the-ons-podcast-1126448/episode-406-drug-resistance-biomarkers-and-their-impact-on-cancer-treatment-choices Text version: https://stenobird.com/podcast/the-ons-podcast-1126448/episode-406-drug-resistance-biomarkers-and-their-impact-on-cancer-treatment-choices.md Podcast: [The ONS Podcast](https://stenobird.com/podcast/the-ons-podcast-1126448) Published: 2026-03-13T08:00:00+00:00 Episode link: https://onsvoice.libsyn.com/episode-406-drug-resistance-biomarkers-and-their-impact-on-cancer-treatment-choices Audio file: https://traffic.libsyn.com/secure/onsvoice/ONSP_406.mp3?dest-id=557038 Processing state: not_requested JSON: https://stenobird.com/v1/public/podcasts/the-ons-podcast-1126448/episodes/episode-406-drug-resistance-biomarkers-and-their-impact-on-cancer-treatment-choices Duration seconds: 1444 ## Resource "Our goal of precision oncology has been to shift to tailored therapies that can help to improve treatment efficacy and ultimately improve patient outcomes. Resistance biomarker testing can help the care team to detect these genomic changes that the tumor may have acquired during therapy that makes the cells resistant to therapy. This information can be extremely helpful when we're talking about making choices about second-line or subsequent-line therapy," ONS member Danielle Fournier, DNP, APRN, AGPCNP-BC, AOCNP ® , advanced practice RN at the University of Texas MD Anderson Cancer Center in Houston, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS ® , manager of oncology nursing practice at ONS, during a conversation about drug resistance biomarker testing. This podcast episode is sponsored by AstraZeneca. ONS is solely responsible for the criteria, objectives, content, quality, and scientific integrity of its programs and publications. Music Credit: " Fireflies and Stardust " by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Episode Notes This episode is not eligible for NCPD credit. ONS Podcast ™ episodes: Episode 389: Biomarker Testing for Non-Small Cell Lung Cancer Episode 373: Biomarker Testing in Prostate Cancer Episode 169: How Biomarker Testing Drives the Use of Targeted Therapies ONS Voice articles: Help Your Patients Understand Biomarker Resistance Testing Key Patient Education Points for Biomarker Resistance Testing Quick Quiz: How Much Do You Know About Drug Resistance in Cancer? Quick Quiz: How Much Do You Know About Somatic Biomarker Resistance Testing? When Targeted Therapy Stops Working, What's Next? Discover How Biomarker Resistance Testing Opens New Doors ONS Biomarker Database Clinical Journal of Oncology Nursing article: Tumor-Agnosti… ## Actions - request_transcript: `POST https://stenobird.com/v1/public/podcasts/the-ons-podcast-1126448/episodes/episode-406-drug-resistance-biomarkers-and-their-impact-on-cancer-treatment-choices/transcription-requests` — Idempotently request low-priority transcript generation for this episode. - read_markdown: `GET https://stenobird.com/podcast/the-ons-podcast-1126448/episode-406-drug-resistance-biomarkers-and-their-impact-on-cancer-treatment-choices.md` — Read the agent-friendly Markdown representation of this episode resource. A page view does not enqueue transcription. Agents should invoke `request_transcript` explicitly when they need this episode processed. ## Transcript Full transcripts are not published on public pages unless there is a clear rights basis.