# 361: pHix Bitter Extracts vs Tri‑GLP: Two Pathways, One Goal — Better Metabolism & Gut‑Brain Balance

Page: https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149/361-phix-bitter-extracts-vs-tri-glp-two-pathways-one-goal-better-metabolism-gut-brain-balance
Text version: https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149/361-phix-bitter-extracts-vs-tri-glp-two-pathways-one-goal-better-metabolism-gut-brain-balance.md
Podcast: [The Natural Alternative - with Madonna Guy](https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149)
Published: 2026-05-18T08:33:10+00:00
Episode link: https://audioboom.com/posts/8904766
Audio file: https://audioboom.com/posts/8904766.mp3?modified=1779093215&sid=5073029&source=rss
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JSON: https://stenobird.com/v1/public/podcasts/the-natural-alternative-with-madonna-guy-5290149/episodes/361-phix-bitter-extracts-vs-tri-glp-two-pathways-one-goal-better-metabolism-gut-brain-balance
Duration seconds: 324

## Resource

TriGLP - madonnaguy.myorygn.co From my clinical perspective, pHix matured hops bitter extracts and Tri‑GLP work on the same metabolic–gut–brain network, but they do so through very different mechanisms. pHix activates T2R bitter receptors in the gut, triggering natural GLP‑1 release and supporting appetite regulation, digestion, and vagal signaling. Tri‑GLP, on the other hand, works downstream by directly activating GLP‑1, GLP‑2, and GIP receptors simultaneously, offering deeper support for gut barrier repair, inflammation reduction, metabolic flexibility, and nervous‑system regulation. While bitter extracts stimulate the body’s own incretin response, Tri‑GLP provides a more comprehensive triple‑pathway activation — and together, they converge on the same biological circuitry disrupted by chronic stress, trauma, and long‑term metabolic imbalance. #Naturopath #NaturopathicMedicine #Kinesiology #HolisticHealth #FunctionalMedicine #IntegrativeHealth #GutBrainAxis #VagusNerve #BitterReceptors #MaturedHops #pHix #TriGLP #GLP1 #GLP2 #GIP #IncretinSystem #MetabolicHealth #GutHealth #GutHealing #Inflammation #ChronicStress #TraumaInformed #ACEScore #DepressionSupport #Neuroinflammation #MetabolicFlexibility #VagalTone #RootCauseHealing #HolisticWeightLoss #NaturalHealthPractitioner #MadonnaGuy #BrisbaneNaturopath #MindBodyConnection #Polyvagal #NeuroimmuneHealth #StressRecovery #HormoneHealth #WholeBodyHealing #FutureOfHealth

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