# 360: DEPRESSIONS Biological Roots: Vagus Nerve, Gut Health & Incretin Hormones/Peptides - GLP1 GLP2 & GIP

Page: https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149/360-depressions-biological-roots-vagus-nerve-gut-health-incretin-hormones-peptides-glp1-glp2-gip
Text version: https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149/360-depressions-biological-roots-vagus-nerve-gut-health-incretin-hormones-peptides-glp1-glp2-gip.md
Podcast: [The Natural Alternative - with Madonna Guy](https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149)
Published: 2026-05-18T05:14:49+00:00
Episode link: https://audioboom.com/posts/8904750
Audio file: https://audioboom.com/posts/8904750.mp3?modified=1779081324&sid=5073029&source=rss
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JSON: https://stenobird.com/v1/public/podcasts/the-natural-alternative-with-madonna-guy-5290149/episodes/360-depressions-biological-roots-vagus-nerve-gut-health-incretin-hormones-peptides-glp1-glp2-gip
Duration seconds: 364

## Resource

madonnaguy.myorygn.co As a naturopath and kinesiologist with over 30 years of clinical experience, I’ve seen firsthand how chronic depression, trauma, and long-term stress create deep biological changes that most treatments simply don’t address. In the video, I explained how the vagus nerve, gut integrity, inflammation, metabolic regulation, and stress hormones all interact as one interconnected system. When someone has lived through early-life trauma or persistent stress, this entire circuit becomes dysregulated — and no amount of “positive thinking” can override biology that’s been pushed into survival mode for years. This is why so many people feel like they’ve “tried everything” yet still struggle. I also introduced the concept of Tri‑GLP, which supports the GLP‑1, GLP‑2, and GIP pathways simultaneously. These pathways regulate appetite, blood sugar, inflammation, gut repair, and even aspects of mood and nervous system function. While bitter receptors can stimulate GLP‑1 release, Tri‑GLP works downstream to support the deeper metabolic, gut, and neuroimmune repair that trauma and chronic stress disrupt. For many people, this triple-pathway support may be the missing biological piece that helps their system finally shift out of survival mode and into healing. 🌟 #Naturopath #NaturopathicMedicine #Kinesiology #HolisticHealth #FunctionalMedicine #IntegrativeHealth #MindBodyConnection #GutBrainAxis #VagusNerve #VagusNerveHealing #TraumaInformed #ACEScore #ChronicDepression #MentalHealthMatters #Neuroinflammation #MetabolicHealth #MetabolicHealing #Incretins #GLP1 #GLP2 #GIP #TriGLP #TripleAgonist #GutHealth #GutHealing #Inflammation #InsulinResistance #IncretinResistance #WeightLossScience #HolisticWeightLoss #RootCauseMedicine #WholeBodyHealing #TraumaHealing #NervousS…

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