# The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498 Page: https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629/the-foods-drinks-and-daily-habits-wrecking-your-brain-surprising-david-perlmutter-1498 Text version: https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629/the-foods-drinks-and-daily-habits-wrecking-your-brain-surprising-david-perlmutter-1498.md Podcast: [The Human Upgrade: Biohacking for Longevity & Performance](https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629) Published: 2026-07-09T08:30:00+00:00 Episode link: https://dts.podtrac.com/redirect.mp3/mgln.ai/e/p394/rss.art19.com/episodes/833b9ae1-b9f5-498b-b98d-d6c779e39511.mp3?rss_browser=BAhJIg90cmFuc2NyaWJyBjoGRVQ%3D--952c5701c84ad333c69d5faa668f8177091704f0 Audio file: https://dts.podtrac.com/redirect.mp3/mgln.ai/e/p394/rss.art19.com/episodes/833b9ae1-b9f5-498b-b98d-d6c779e39511.mp3?rss_browser=BAhJIg90cmFuc2NyaWJyBjoGRVQ%3D--952c5701c84ad333c69d5faa668f8177091704f0 Processing state: not_requested JSON: https://stenobird.com/v1/public/podcasts/the-human-upgrade-biohacking-for-longevity-performance-1031629/episodes/the-foods-drinks-and-daily-habits-wrecking-your-brain-surprising-david-perlmutter-1498 Duration seconds: 3184 ## Resource Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk  Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it.    Get Dr. Perlmutter’s new book Brain Defenders : https://drperlmutter.com/books/brain-defenders/     Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience.    Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising… ## Actions - request_transcript: `POST https://stenobird.com/v1/public/podcasts/the-human-upgrade-biohacking-for-longevity-performance-1031629/episodes/the-foods-drinks-and-daily-habits-wrecking-your-brain-surprising-david-perlmutter-1498/transcription-requests` — Idempotently request low-priority transcript generation for this episode. - read_markdown: `GET https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629/the-foods-drinks-and-daily-habits-wrecking-your-brain-surprising-david-perlmutter-1498.md` — Read the agent-friendly Markdown representation of this episode resource. A page view does not enqueue transcription. Agents should invoke `request_transcript` explicitly when they need this episode processed. ## Transcript Full transcripts are not published on public pages unless there is a clear rights basis.