# Why Your Gut Is Running Your Immune System (And What to Do When It’s Not Working)

Page: https://stenobird.com/podcast/the-goode-health-functional-medicine-longevity-autoimmune-6433631/why-your-gut-is-running-your-immune-system-and-what-to-do-when-it-s-not-working
Text version: https://stenobird.com/podcast/the-goode-health-functional-medicine-longevity-autoimmune-6433631/why-your-gut-is-running-your-immune-system-and-what-to-do-when-it-s-not-working.md
Podcast: [The Goode Health: Functional Medicine, Longevity & Autoimmune](https://stenobird.com/podcast/the-goode-health-functional-medicine-longevity-autoimmune-6433631)
Published: 2026-03-02T07:30:00+00:00
Episode link: https://www.nicolegoodehealth.com
Audio file: https://episodes.captivate.fm/episode/736976a6-dcf2-454a-84fc-fe0bfd65165d.mp3
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Duration seconds: 1308

## Resource

Your gut isn’t just digesting food, it’s directing your immune system. Around 70% of your immune cells live in the gut, and when that relationship becomes disrupted, the consequences ripple far beyond digestion. In this episode, we break down the gut-immune axis and explain why symptoms like fatigue, brain fog, recurrent infections, skin flare-ups, IBS, and autoimmune disease often trace back to gut dysfunction. 03:15 – What Is the Gut-Immune Axis? (70% of Your Immune System Lives in Your Gut) 05:00 – The Gut Barrier & Increased Intestinal Permeability (“Leaky Gut”) 06:50 – The 6 Biggest Gut-Immune Disruptors 10:40 – How Stress, Sleep & the Microbiome Create a Vicious Cycle 12:40 – Signs Your Gut-Immune Axis Is Under Stress 14:30 – Why Fatigue, Brain Fog & Low Mood Can Be Immune-Driven 15:40 – The Functional Medicine 4R Protocol for Gut Repair 18:30 – Key Nutrients for Gut Lining Repair & Immune Regulation 19:45 – Why You Can’t Heal the Gut Without Addressing Chronic Stress If you’re tired of managing isolated symptoms and want to understand the root cause behind immune dysfunction, this episode joins the dots and shows you where to start. RESOURCES: Grab all the links and resources mentioned in this episode at https://www.nicolegoodehealth.com/the-goode-health-podcast/episode-115 DISCLAIMER: The content in this podcast and related website is not intended to be a substitute for medical advice. It is not intended to be used to diagnose or treat, instead it is designed to help educate and inspire. Always seek the advice of a professional medical practitioner or qualified health practitioner. Never ignore or disregard advice given to you based on information in this podcast or related website and do not delay in seeking medical advice.

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